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Modeling Chemical Interaction Profiles: II. Molecular Docking, Spectral Data-Activity Relationship, and Structure-Activity Relationship Models for Potent and Weak Inhibitors of Cytochrome P450 CYP3A4 Isozyme

Polypharmacy increasingly has become a topic of public health concern, particularly as the U.S. population ages. Drug labels often contain insufficient information to enable the clinician to safely use multiple drugs. Because many of the drugs are bio-transformed by cytochrome P450 (CYP) enzymes, in...

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Detalles Bibliográficos
Autores principales:	Tie, Yunfeng, McPhail, Brooks, Hong, Huixiao, Pearce, Bruce A., Schnackenberg, Laura K., Ge, Weigong, Buzatu, Dan A., Wilkes, Jon G., Fuscoe, James C., Tong, Weida, Fowler, Bruce A., Beger, Richard D., Demchuk, Eugene
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268819/ https://www.ncbi.nlm.nih.gov/pubmed/22421793 http://dx.doi.org/10.3390/molecules17033407

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