Effect of Paeonol on Antioxidant and Immune Regulatory Activity in Hepatocellular Carcinoma Rats

The study investigated the immunity and antioxidant potential of paeonol by employing a hepatocellular carcinoma (HCC) rat model. Three doses of paeonol (20, 40, 60 mg/kg b.w. orally) were administrated to diethylnitrosamine (DEN)-induced HCC rats. Results showed that paeonol significantly reduced t...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Bendong, Ning, Mingliang, Yang, Guangshun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268820/
https://www.ncbi.nlm.nih.gov/pubmed/22522397
http://dx.doi.org/10.3390/molecules17044672
_version_ 1783376374689431552
author Chen, Bendong
Ning, Mingliang
Yang, Guangshun
author_facet Chen, Bendong
Ning, Mingliang
Yang, Guangshun
author_sort Chen, Bendong
collection PubMed
description The study investigated the immunity and antioxidant potential of paeonol by employing a hepatocellular carcinoma (HCC) rat model. Three doses of paeonol (20, 40, 60 mg/kg b.w. orally) were administrated to diethylnitrosamine (DEN)-induced HCC rats. Results showed that paeonol significantly reduced the serum AST, ALT, ALP, GGT, AFU and liver MDA levels, increased serum WBC, TP, ALB, A/G, TNF-α and IFN-γ and liver antioxidant enzymes activities (SOD, CAT, GSH-Px, GR) in HCC rats. Altogether, these results suggest that the paeonol could effectively decrease oxidative injury and improve immunity function in HCC rats.
format Online
Article
Text
id pubmed-6268820
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62688202018-12-11 Effect of Paeonol on Antioxidant and Immune Regulatory Activity in Hepatocellular Carcinoma Rats Chen, Bendong Ning, Mingliang Yang, Guangshun Molecules Article The study investigated the immunity and antioxidant potential of paeonol by employing a hepatocellular carcinoma (HCC) rat model. Three doses of paeonol (20, 40, 60 mg/kg b.w. orally) were administrated to diethylnitrosamine (DEN)-induced HCC rats. Results showed that paeonol significantly reduced the serum AST, ALT, ALP, GGT, AFU and liver MDA levels, increased serum WBC, TP, ALB, A/G, TNF-α and IFN-γ and liver antioxidant enzymes activities (SOD, CAT, GSH-Px, GR) in HCC rats. Altogether, these results suggest that the paeonol could effectively decrease oxidative injury and improve immunity function in HCC rats. MDPI 2012-04-20 /pmc/articles/PMC6268820/ /pubmed/22522397 http://dx.doi.org/10.3390/molecules17044672 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Chen, Bendong
Ning, Mingliang
Yang, Guangshun
Effect of Paeonol on Antioxidant and Immune Regulatory Activity in Hepatocellular Carcinoma Rats
title Effect of Paeonol on Antioxidant and Immune Regulatory Activity in Hepatocellular Carcinoma Rats
title_full Effect of Paeonol on Antioxidant and Immune Regulatory Activity in Hepatocellular Carcinoma Rats
title_fullStr Effect of Paeonol on Antioxidant and Immune Regulatory Activity in Hepatocellular Carcinoma Rats
title_full_unstemmed Effect of Paeonol on Antioxidant and Immune Regulatory Activity in Hepatocellular Carcinoma Rats
title_short Effect of Paeonol on Antioxidant and Immune Regulatory Activity in Hepatocellular Carcinoma Rats
title_sort effect of paeonol on antioxidant and immune regulatory activity in hepatocellular carcinoma rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268820/
https://www.ncbi.nlm.nih.gov/pubmed/22522397
http://dx.doi.org/10.3390/molecules17044672
work_keys_str_mv AT chenbendong effectofpaeonolonantioxidantandimmuneregulatoryactivityinhepatocellularcarcinomarats
AT ningmingliang effectofpaeonolonantioxidantandimmuneregulatoryactivityinhepatocellularcarcinomarats
AT yangguangshun effectofpaeonolonantioxidantandimmuneregulatoryactivityinhepatocellularcarcinomarats

Ejemplares similares