Ursolic Acid Inhibits Cigarette Smoke Extract-Induced Human Bronchial Epithelial Cell Injury and Prevents Development of Lung Cancer

Cigarette smoking is the main cause of chronic obstructive pulmonary disease and lung cancer. The present study was aimed to explore the chemopreventive effect of ursolic acid (UA) on these diseases. In the CSE treated normal human bronchial epithelial cell model, UA alleviated cytotoxicity caused b...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Wenbo, Tan, Xiaobin, Shu, Luan, Sun, Hanyan, Song, Jie, Jin, Ping, Yu, Siming, Sun, Min, Jia, Xiaobin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268827/
https://www.ncbi.nlm.nih.gov/pubmed/22858837
http://dx.doi.org/10.3390/molecules17089104
_version_ 1783376376333598720
author Liu, Wenbo
Tan, Xiaobin
Shu, Luan
Sun, Hanyan
Song, Jie
Jin, Ping
Yu, Siming
Sun, Min
Jia, Xiaobin
author_facet Liu, Wenbo
Tan, Xiaobin
Shu, Luan
Sun, Hanyan
Song, Jie
Jin, Ping
Yu, Siming
Sun, Min
Jia, Xiaobin
author_sort Liu, Wenbo
collection PubMed
description Cigarette smoking is the main cause of chronic obstructive pulmonary disease and lung cancer. The present study was aimed to explore the chemopreventive effect of ursolic acid (UA) on these diseases. In the CSE treated normal human bronchial epithelial cell model, UA alleviated cytotoxicity caused by CSE, recovered the intracellular redox balance, and relieved the stimulation of external deleterious factors as well. UA mitigated CSE-induced DNA damage through the Nrf2 (nuclear factor erythroid 2-related factor 2) pathway. Moreover, UA inhibited lung cancer development in the model established by A549 cells in nude mice in vivo. For the first time, our results indicate that UA could be developed as a potential lung cancer chemopreventive agent.
format Online
Article
Text
id pubmed-6268827
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62688272018-12-12 Ursolic Acid Inhibits Cigarette Smoke Extract-Induced Human Bronchial Epithelial Cell Injury and Prevents Development of Lung Cancer Liu, Wenbo Tan, Xiaobin Shu, Luan Sun, Hanyan Song, Jie Jin, Ping Yu, Siming Sun, Min Jia, Xiaobin Molecules Article Cigarette smoking is the main cause of chronic obstructive pulmonary disease and lung cancer. The present study was aimed to explore the chemopreventive effect of ursolic acid (UA) on these diseases. In the CSE treated normal human bronchial epithelial cell model, UA alleviated cytotoxicity caused by CSE, recovered the intracellular redox balance, and relieved the stimulation of external deleterious factors as well. UA mitigated CSE-induced DNA damage through the Nrf2 (nuclear factor erythroid 2-related factor 2) pathway. Moreover, UA inhibited lung cancer development in the model established by A549 cells in nude mice in vivo. For the first time, our results indicate that UA could be developed as a potential lung cancer chemopreventive agent. MDPI 2012-08-02 /pmc/articles/PMC6268827/ /pubmed/22858837 http://dx.doi.org/10.3390/molecules17089104 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Liu, Wenbo
Tan, Xiaobin
Shu, Luan
Sun, Hanyan
Song, Jie
Jin, Ping
Yu, Siming
Sun, Min
Jia, Xiaobin
Ursolic Acid Inhibits Cigarette Smoke Extract-Induced Human Bronchial Epithelial Cell Injury and Prevents Development of Lung Cancer
title Ursolic Acid Inhibits Cigarette Smoke Extract-Induced Human Bronchial Epithelial Cell Injury and Prevents Development of Lung Cancer
title_full Ursolic Acid Inhibits Cigarette Smoke Extract-Induced Human Bronchial Epithelial Cell Injury and Prevents Development of Lung Cancer
title_fullStr Ursolic Acid Inhibits Cigarette Smoke Extract-Induced Human Bronchial Epithelial Cell Injury and Prevents Development of Lung Cancer
title_full_unstemmed Ursolic Acid Inhibits Cigarette Smoke Extract-Induced Human Bronchial Epithelial Cell Injury and Prevents Development of Lung Cancer
title_short Ursolic Acid Inhibits Cigarette Smoke Extract-Induced Human Bronchial Epithelial Cell Injury and Prevents Development of Lung Cancer
title_sort ursolic acid inhibits cigarette smoke extract-induced human bronchial epithelial cell injury and prevents development of lung cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268827/
https://www.ncbi.nlm.nih.gov/pubmed/22858837
http://dx.doi.org/10.3390/molecules17089104
work_keys_str_mv AT liuwenbo ursolicacidinhibitscigarettesmokeextractinducedhumanbronchialepithelialcellinjuryandpreventsdevelopmentoflungcancer
AT tanxiaobin ursolicacidinhibitscigarettesmokeextractinducedhumanbronchialepithelialcellinjuryandpreventsdevelopmentoflungcancer
AT shuluan ursolicacidinhibitscigarettesmokeextractinducedhumanbronchialepithelialcellinjuryandpreventsdevelopmentoflungcancer
AT sunhanyan ursolicacidinhibitscigarettesmokeextractinducedhumanbronchialepithelialcellinjuryandpreventsdevelopmentoflungcancer
AT songjie ursolicacidinhibitscigarettesmokeextractinducedhumanbronchialepithelialcellinjuryandpreventsdevelopmentoflungcancer
AT jinping ursolicacidinhibitscigarettesmokeextractinducedhumanbronchialepithelialcellinjuryandpreventsdevelopmentoflungcancer
AT yusiming ursolicacidinhibitscigarettesmokeextractinducedhumanbronchialepithelialcellinjuryandpreventsdevelopmentoflungcancer
AT sunmin ursolicacidinhibitscigarettesmokeextractinducedhumanbronchialepithelialcellinjuryandpreventsdevelopmentoflungcancer
AT jiaxiaobin ursolicacidinhibitscigarettesmokeextractinducedhumanbronchialepithelialcellinjuryandpreventsdevelopmentoflungcancer

Ejemplares similares