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Quinoline-3-carboxamide Derivatives as Potential Cholesteryl Ester Transfer Protein Inhibitors
A series of novel quinoline-3-carboxamide derivatives 10–17 and 23–27 were designed and synthesized as cholesteryl ester transfer protein (CETP) inhibitors. All of them exhibited activity against CETP. Particularly, compounds 24 and 26 displayed the best activity against CETP with the same inhibitor...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268837/ https://www.ncbi.nlm.nih.gov/pubmed/22572932 http://dx.doi.org/10.3390/molecules17055497 |
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author | Li, Wen-Yan Xiong, Xu-Qiong Zhao, Dong-Mei Shi, Yu-Fang Yang, Zhi-Heng Yu, Chao Fan, Pei-Wei Cheng, Mao-Sheng Shen, Jing-Kang |
author_facet | Li, Wen-Yan Xiong, Xu-Qiong Zhao, Dong-Mei Shi, Yu-Fang Yang, Zhi-Heng Yu, Chao Fan, Pei-Wei Cheng, Mao-Sheng Shen, Jing-Kang |
author_sort | Li, Wen-Yan |
collection | PubMed |
description | A series of novel quinoline-3-carboxamide derivatives 10–17 and 23–27 were designed and synthesized as cholesteryl ester transfer protein (CETP) inhibitors. All of them exhibited activity against CETP. Particularly, compounds 24 and 26 displayed the best activity against CETP with the same inhibitory rate of 80.1%. |
format | Online Article Text |
id | pubmed-6268837 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62688372018-12-20 Quinoline-3-carboxamide Derivatives as Potential Cholesteryl Ester Transfer Protein Inhibitors Li, Wen-Yan Xiong, Xu-Qiong Zhao, Dong-Mei Shi, Yu-Fang Yang, Zhi-Heng Yu, Chao Fan, Pei-Wei Cheng, Mao-Sheng Shen, Jing-Kang Molecules Article A series of novel quinoline-3-carboxamide derivatives 10–17 and 23–27 were designed and synthesized as cholesteryl ester transfer protein (CETP) inhibitors. All of them exhibited activity against CETP. Particularly, compounds 24 and 26 displayed the best activity against CETP with the same inhibitory rate of 80.1%. MDPI 2012-05-09 /pmc/articles/PMC6268837/ /pubmed/22572932 http://dx.doi.org/10.3390/molecules17055497 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Li, Wen-Yan Xiong, Xu-Qiong Zhao, Dong-Mei Shi, Yu-Fang Yang, Zhi-Heng Yu, Chao Fan, Pei-Wei Cheng, Mao-Sheng Shen, Jing-Kang Quinoline-3-carboxamide Derivatives as Potential Cholesteryl Ester Transfer Protein Inhibitors |
title | Quinoline-3-carboxamide Derivatives as Potential Cholesteryl Ester Transfer Protein Inhibitors |
title_full | Quinoline-3-carboxamide Derivatives as Potential Cholesteryl Ester Transfer Protein Inhibitors |
title_fullStr | Quinoline-3-carboxamide Derivatives as Potential Cholesteryl Ester Transfer Protein Inhibitors |
title_full_unstemmed | Quinoline-3-carboxamide Derivatives as Potential Cholesteryl Ester Transfer Protein Inhibitors |
title_short | Quinoline-3-carboxamide Derivatives as Potential Cholesteryl Ester Transfer Protein Inhibitors |
title_sort | quinoline-3-carboxamide derivatives as potential cholesteryl ester transfer protein inhibitors |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268837/ https://www.ncbi.nlm.nih.gov/pubmed/22572932 http://dx.doi.org/10.3390/molecules17055497 |
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