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Quinoline-3-carboxamide Derivatives as Potential Cholesteryl Ester Transfer Protein Inhibitors

A series of novel quinoline-3-carboxamide derivatives 10–17 and 23–27 were designed and synthesized as cholesteryl ester transfer protein (CETP) inhibitors. All of them exhibited activity against CETP. Particularly, compounds 24 and 26 displayed the best activity against CETP with the same inhibitor...

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Autores principales: Li, Wen-Yan, Xiong, Xu-Qiong, Zhao, Dong-Mei, Shi, Yu-Fang, Yang, Zhi-Heng, Yu, Chao, Fan, Pei-Wei, Cheng, Mao-Sheng, Shen, Jing-Kang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268837/
https://www.ncbi.nlm.nih.gov/pubmed/22572932
http://dx.doi.org/10.3390/molecules17055497
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author Li, Wen-Yan
Xiong, Xu-Qiong
Zhao, Dong-Mei
Shi, Yu-Fang
Yang, Zhi-Heng
Yu, Chao
Fan, Pei-Wei
Cheng, Mao-Sheng
Shen, Jing-Kang
author_facet Li, Wen-Yan
Xiong, Xu-Qiong
Zhao, Dong-Mei
Shi, Yu-Fang
Yang, Zhi-Heng
Yu, Chao
Fan, Pei-Wei
Cheng, Mao-Sheng
Shen, Jing-Kang
author_sort Li, Wen-Yan
collection PubMed
description A series of novel quinoline-3-carboxamide derivatives 10–17 and 23–27 were designed and synthesized as cholesteryl ester transfer protein (CETP) inhibitors. All of them exhibited activity against CETP. Particularly, compounds 24 and 26 displayed the best activity against CETP with the same inhibitory rate of 80.1%.
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spelling pubmed-62688372018-12-20 Quinoline-3-carboxamide Derivatives as Potential Cholesteryl Ester Transfer Protein Inhibitors Li, Wen-Yan Xiong, Xu-Qiong Zhao, Dong-Mei Shi, Yu-Fang Yang, Zhi-Heng Yu, Chao Fan, Pei-Wei Cheng, Mao-Sheng Shen, Jing-Kang Molecules Article A series of novel quinoline-3-carboxamide derivatives 10–17 and 23–27 were designed and synthesized as cholesteryl ester transfer protein (CETP) inhibitors. All of them exhibited activity against CETP. Particularly, compounds 24 and 26 displayed the best activity against CETP with the same inhibitory rate of 80.1%. MDPI 2012-05-09 /pmc/articles/PMC6268837/ /pubmed/22572932 http://dx.doi.org/10.3390/molecules17055497 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Li, Wen-Yan
Xiong, Xu-Qiong
Zhao, Dong-Mei
Shi, Yu-Fang
Yang, Zhi-Heng
Yu, Chao
Fan, Pei-Wei
Cheng, Mao-Sheng
Shen, Jing-Kang
Quinoline-3-carboxamide Derivatives as Potential Cholesteryl Ester Transfer Protein Inhibitors
title Quinoline-3-carboxamide Derivatives as Potential Cholesteryl Ester Transfer Protein Inhibitors
title_full Quinoline-3-carboxamide Derivatives as Potential Cholesteryl Ester Transfer Protein Inhibitors
title_fullStr Quinoline-3-carboxamide Derivatives as Potential Cholesteryl Ester Transfer Protein Inhibitors
title_full_unstemmed Quinoline-3-carboxamide Derivatives as Potential Cholesteryl Ester Transfer Protein Inhibitors
title_short Quinoline-3-carboxamide Derivatives as Potential Cholesteryl Ester Transfer Protein Inhibitors
title_sort quinoline-3-carboxamide derivatives as potential cholesteryl ester transfer protein inhibitors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268837/
https://www.ncbi.nlm.nih.gov/pubmed/22572932
http://dx.doi.org/10.3390/molecules17055497
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