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The Effects of Davallic Acid from Davallia divaricata Blume on Apoptosis Induction in A549 Lung Cancer Cells

Traditional or folk medicinal herbs continue to be prescribed in the treatment of various diseases and conditions in many cultures. Recent scientific efforts have focused on the potential roles of extracts of traditional herbs as alternative and complementary medications for cancer treatment. In Tai...

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Autores principales: Cheng, An-Sheng, Chang, We-Chang, Cheng, Yu-Hsiang, Chen, Kai-Yu, Chen, Kai-Hsien, Chang, Tsu-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268845/
https://www.ncbi.nlm.nih.gov/pubmed/23117433
http://dx.doi.org/10.3390/molecules171112938
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author Cheng, An-Sheng
Chang, We-Chang
Cheng, Yu-Hsiang
Chen, Kai-Yu
Chen, Kai-Hsien
Chang, Tsu-Liang
author_facet Cheng, An-Sheng
Chang, We-Chang
Cheng, Yu-Hsiang
Chen, Kai-Yu
Chen, Kai-Hsien
Chang, Tsu-Liang
author_sort Cheng, An-Sheng
collection PubMed
description Traditional or folk medicinal herbs continue to be prescribed in the treatment of various diseases and conditions in many cultures. Recent scientific efforts have focused on the potential roles of extracts of traditional herbs as alternative and complementary medications for cancer treatment. In Taiwan, Davallia divaricata Blume has been traditionally employed in folk medicine for therapy of lung cancer, davallic acid being the major active compound of D. divaricata Blume. In this study, we investigated the inhibitory activity of davallic acid on the proliferation of A549 lung cancer cells. Davallic acid was extracted from D. divaricata Blume, and its effects on cell viability, cell cycle distribution, ROS level, and apoptotic protein expression in A549 cells were determined. Davallic acid significantly induced reactive oxygen species (ROS) generation as well as caspase-3, -8, and -9 activation, thereby repressing A549 cell growth and elevating apoptotic activity. Since lung cancer has a high incidence of recurrence, these results indicate that davallic acid may have the potential to be a natural anti-lung cancer compound, and may provide a basis for further study of its use in combating cancer.
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spelling pubmed-62688452018-12-13 The Effects of Davallic Acid from Davallia divaricata Blume on Apoptosis Induction in A549 Lung Cancer Cells Cheng, An-Sheng Chang, We-Chang Cheng, Yu-Hsiang Chen, Kai-Yu Chen, Kai-Hsien Chang, Tsu-Liang Molecules Article Traditional or folk medicinal herbs continue to be prescribed in the treatment of various diseases and conditions in many cultures. Recent scientific efforts have focused on the potential roles of extracts of traditional herbs as alternative and complementary medications for cancer treatment. In Taiwan, Davallia divaricata Blume has been traditionally employed in folk medicine for therapy of lung cancer, davallic acid being the major active compound of D. divaricata Blume. In this study, we investigated the inhibitory activity of davallic acid on the proliferation of A549 lung cancer cells. Davallic acid was extracted from D. divaricata Blume, and its effects on cell viability, cell cycle distribution, ROS level, and apoptotic protein expression in A549 cells were determined. Davallic acid significantly induced reactive oxygen species (ROS) generation as well as caspase-3, -8, and -9 activation, thereby repressing A549 cell growth and elevating apoptotic activity. Since lung cancer has a high incidence of recurrence, these results indicate that davallic acid may have the potential to be a natural anti-lung cancer compound, and may provide a basis for further study of its use in combating cancer. MDPI 2012-11-01 /pmc/articles/PMC6268845/ /pubmed/23117433 http://dx.doi.org/10.3390/molecules171112938 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Cheng, An-Sheng
Chang, We-Chang
Cheng, Yu-Hsiang
Chen, Kai-Yu
Chen, Kai-Hsien
Chang, Tsu-Liang
The Effects of Davallic Acid from Davallia divaricata Blume on Apoptosis Induction in A549 Lung Cancer Cells
title The Effects of Davallic Acid from Davallia divaricata Blume on Apoptosis Induction in A549 Lung Cancer Cells
title_full The Effects of Davallic Acid from Davallia divaricata Blume on Apoptosis Induction in A549 Lung Cancer Cells
title_fullStr The Effects of Davallic Acid from Davallia divaricata Blume on Apoptosis Induction in A549 Lung Cancer Cells
title_full_unstemmed The Effects of Davallic Acid from Davallia divaricata Blume on Apoptosis Induction in A549 Lung Cancer Cells
title_short The Effects of Davallic Acid from Davallia divaricata Blume on Apoptosis Induction in A549 Lung Cancer Cells
title_sort effects of davallic acid from davallia divaricata blume on apoptosis induction in a549 lung cancer cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268845/
https://www.ncbi.nlm.nih.gov/pubmed/23117433
http://dx.doi.org/10.3390/molecules171112938
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