Silica Gel-Mediated Organic Reactions under Organic Solvent-Free Conditions

Silica gel was found to be an excellent medium for some useful organic transformations under organic solvent-free conditions, such as (1) the Friedel-Crafts-type nitration of arenes using commercial aqueous 69% nitric acid alone at room temperature, (2) one-pot Wittig-type olefination of aldehydes w...

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Detalles Bibliográficos
Autores principales: Onitsuka, Satoaki, Jin, Yong Zhi, Shaikh, Ajam C., Furuno, Hiroshi, Inanaga, Junji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268860/
https://www.ncbi.nlm.nih.gov/pubmed/23018922
http://dx.doi.org/10.3390/molecules171011469
Descripción
Sumario:Silica gel was found to be an excellent medium for some useful organic transformations under organic solvent-free conditions, such as (1) the Friedel-Crafts-type nitration of arenes using commercial aqueous 69% nitric acid alone at room temperature, (2) one-pot Wittig-type olefination of aldehydes with activated organic halides in the presence of tributyl- or triphenylphosphine and Hunig’s base, and (3) the Morita-Baylis-Hillman reaction of aldehydes with methyl acrylate. After the reactions, the desired products were easily obtained in good to excellent yields through simple manipulation.

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