Silica Gel-Mediated Organic Reactions under Organic Solvent-Free Conditions

Silica gel was found to be an excellent medium for some useful organic transformations under organic solvent-free conditions, such as (1) the Friedel-Crafts-type nitration of arenes using commercial aqueous 69% nitric acid alone at room temperature, (2) one-pot Wittig-type olefination of aldehydes w...

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Autores principales: Onitsuka, Satoaki, Jin, Yong Zhi, Shaikh, Ajam C., Furuno, Hiroshi, Inanaga, Junji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268860/
https://www.ncbi.nlm.nih.gov/pubmed/23018922
http://dx.doi.org/10.3390/molecules171011469
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author Onitsuka, Satoaki
Jin, Yong Zhi
Shaikh, Ajam C.
Furuno, Hiroshi
Inanaga, Junji
author_facet Onitsuka, Satoaki
Jin, Yong Zhi
Shaikh, Ajam C.
Furuno, Hiroshi
Inanaga, Junji
author_sort Onitsuka, Satoaki
collection PubMed
description Silica gel was found to be an excellent medium for some useful organic transformations under organic solvent-free conditions, such as (1) the Friedel-Crafts-type nitration of arenes using commercial aqueous 69% nitric acid alone at room temperature, (2) one-pot Wittig-type olefination of aldehydes with activated organic halides in the presence of tributyl- or triphenylphosphine and Hunig’s base, and (3) the Morita-Baylis-Hillman reaction of aldehydes with methyl acrylate. After the reactions, the desired products were easily obtained in good to excellent yields through simple manipulation.
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spelling pubmed-62688602018-12-12 Silica Gel-Mediated Organic Reactions under Organic Solvent-Free Conditions Onitsuka, Satoaki Jin, Yong Zhi Shaikh, Ajam C. Furuno, Hiroshi Inanaga, Junji Molecules Article Silica gel was found to be an excellent medium for some useful organic transformations under organic solvent-free conditions, such as (1) the Friedel-Crafts-type nitration of arenes using commercial aqueous 69% nitric acid alone at room temperature, (2) one-pot Wittig-type olefination of aldehydes with activated organic halides in the presence of tributyl- or triphenylphosphine and Hunig’s base, and (3) the Morita-Baylis-Hillman reaction of aldehydes with methyl acrylate. After the reactions, the desired products were easily obtained in good to excellent yields through simple manipulation. MDPI 2012-09-27 /pmc/articles/PMC6268860/ /pubmed/23018922 http://dx.doi.org/10.3390/molecules171011469 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Onitsuka, Satoaki
Jin, Yong Zhi
Shaikh, Ajam C.
Furuno, Hiroshi
Inanaga, Junji
Silica Gel-Mediated Organic Reactions under Organic Solvent-Free Conditions
title Silica Gel-Mediated Organic Reactions under Organic Solvent-Free Conditions
title_full Silica Gel-Mediated Organic Reactions under Organic Solvent-Free Conditions
title_fullStr Silica Gel-Mediated Organic Reactions under Organic Solvent-Free Conditions
title_full_unstemmed Silica Gel-Mediated Organic Reactions under Organic Solvent-Free Conditions
title_short Silica Gel-Mediated Organic Reactions under Organic Solvent-Free Conditions
title_sort silica gel-mediated organic reactions under organic solvent-free conditions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268860/
https://www.ncbi.nlm.nih.gov/pubmed/23018922
http://dx.doi.org/10.3390/molecules171011469
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AT jinyongzhi silicagelmediatedorganicreactionsunderorganicsolventfreeconditions
AT shaikhajamc silicagelmediatedorganicreactionsunderorganicsolventfreeconditions
AT furunohiroshi silicagelmediatedorganicreactionsunderorganicsolventfreeconditions
AT inanagajunji silicagelmediatedorganicreactionsunderorganicsolventfreeconditions

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