Cargando…

Synthesis and Biological Activity of Some 3-(4-(Substituted)-piperazin-1-yl)cinnolines

A new series of 6-substituted-4-methyl-3-(4-arylpiperazin-1-yl)cinnolines 8–10 were synthesized as potential antifungal agents via intramolecular cyclization of the respective 1-(2-arylhydrazono)-1-(4-arylpiperazin-1-yl)propan-2-ones 5–7, mediated by polyphosphoric acid (PPA). The amidrazones themse...

Descripción completa

Detalles Bibliográficos
Autores principales:	Awad, Eman D., El-Abadelah, Mustafa M., Matar, Suzan, Zihlif, Malek A., Naffa, Randa G., Al-Momani, Ehab Q., Mubarak, Mohammad S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268863/ https://www.ncbi.nlm.nih.gov/pubmed/22205089 http://dx.doi.org/10.3390/molecules17010227

Ejemplares similares

Synthesis, and Antitumor Activity of Some N1-(Coumarin-7-yl) Amidrazones and Related Congeners
por: Mustafa, Mohammad S., et al.
Publicado: (2011)

Preparation of 3-Substituted Isoindolin-1-one, Cinnoline, and 1,2,4-[e]-Benzotriazine Derivatives
por: El Dhaibi, Fatat B., et al.
Publicado: (2022)

Cinnoline Scaffold—A Molecular Heart of Medicinal Chemistry?
por: Szumilak, Marta, et al.
Publicado: (2019)

Synthesis and chemosensing properties of cinnoline-containing poly(arylene ethynylene)s
por: Danilkina, Natalia A, et al.
Publicado: (2015)

New 7-[4-(4-(un)Substituted)piperazine-1-carbonyl]-piperazin-1-yl] Derivatives of Fluoroquinolone: Synthesis and Antimicrobial Evaluation
por: Chen, Po-Ting, et al.
Publicado: (2013)

4-[3-(Trifluoromethyl)phenyl]-5,6,7,8-tetrahydrocinnolin-3(2H)-one
por: Wang, Xin, et al.
Publicado: (2008)

An intronic single-nucleotide polymorphism (rs13217795) in FOXO3 is associated with asthma and allergic rhinitis: a case–case–control study
por: Amarin, Justin Z., et al.
Publicado: (2017)

The antiangiogenic activities of ethanolic crude extracts of four Salvia species
por: Zihlif, Malek, et al.
Publicado: (2013)

Correction to: The antiangiogenic activities of ethanolic crude extracts of four Salvia species
por: Zihlif, Malek, et al.
Publicado: (2018)

Substituted Piperazines as Novel Potential Radioprotective Agents
por: Filipova, Alzbeta, et al.
Publicado: (2020)

De Novo Assembly of Highly Substituted Morpholines and Piperazines
por: Patil, Pravin, et al.
Publicado: (2017)

Synthesis and Properties of 6-Aryl-4-azidocinnolines and 6-Aryl-4-(1,2,3-1H-triazol-1-yl)cinnolines
por: Danilkina, Natalia A., et al.
Publicado: (2019)

Microwave assisted one-pot green synthesis of cinnoline derivatives inside natural sporopollenin microcapsules
por: Dyab, Amro K. F., et al.
Publicado: (2018)

3-(4-Methylpiperazin-1-yl)isobenzofuran-1(3H)-one
por: Odabaşoğlu, Mustafa, et al.
Publicado: (2008)

1-[Bis(4-fluorophenyl)methyl]piperazine
por: Dayananda, A. S., et al.
Publicado: (2012)

Iridium-Catalyzed Regio- and Diastereoselective Synthesis of C-Substituted Piperazines
por: Tarifa, Luis, et al.
Publicado: (2023)

7-Chloro-4-(piperazin-1-yl)quinoline
por: Kulkarni, Amol A., et al.
Publicado: (2012)

Crystal structures of 4-(pyrimidin-2-yl)piperazin-1-ium chloride and 4-(pyrimidin-2-yl)piperazin-1-ium nitrate
por: Yamuna, Thammarse S., et al.
Publicado: (2014)

1,2,3,6,7,8-Hexahydrocinnolino[5,4,3-cde]cinnoline
por: Gao, Zhi-Qiang
Publicado: (2009)

4-Azidocinnoline—Cinnoline-4-amine Pair as a New Fluorogenic and Fluorochromic Environment-Sensitive Probe
por: Danilkina, Natalia A., et al.
Publicado: (2021)

Dual PTP1B/TC-PTP Inhibitors: Biological Evaluation of 3-(Hydroxymethyl)cinnoline-4(1H)-Ones
por: Derkach, Kira V., et al.
Publicado: (2023)

Synthesis and Structure-Activity Relationship Analysis of 5-HT(7) Receptor Antagonists: Piperazin-1-yl Substituted Unfused Heterobiaryls
por: Strekowski, Lucjan, et al.
Publicado: (2016)

1-Tosyl-4-[2-(trifluoromethyl)benzyl]piperazine
por: Sreenivasa, S., et al.
Publicado: (2013)

Palladium-Catalyzed Modular Synthesis of Substituted Piperazines and Related Nitrogen Heterocycles
por: Montgomery, Thomas D., et al.
Publicado: (2016)

5-Methyl-3,3-bis(4-methylpiperazin-1-yl)-1-[2-(4-methylpiperazin-1-yl)ethyl]indolin-2-one
por: Lin, Hui-Hui, et al.
Publicado: (2012)

Crystal structure of 3-(3-oxo-2,3,4,4a,5,6-hexahydrobenzo[h]cinnolin-2-yl)propionic acid
por: Meneghetti, Fiorella, et al.
Publicado: (2014)

4-(4-Carboxybenzyl)-1-methylpiperazin-1-ium picrate
por: Li, Hongqi, et al.
Publicado: (2009)

2,2′-(Piperazine-1,4-diyl)diacetonitrile
por: Gao, Wei, et al.
Publicado: (2012)

4-(o-Tolyl)piperazin-1-ium chloride
por: Fun, Hoong-Kun, et al.
Publicado: (2011)

4-(Methylsulfonyl)piperazin-1-ium chloride
por: Fun, Hoong-Kun, et al.
Publicado: (2010)

1,4-Bis(2-diazoacetyl)piperazine
por: Kaupang, Åsmund, et al.
Publicado: (2013)

Tuneable access to indole, indolone, and cinnoline derivatives from a common 1,4-diketone Michael acceptor
por: El-Marrouki, Dalel, et al.
Publicado: (2020)

Optimization and Antibacterial Evaluation of Novel 3-(5-Fluoropyridine-3-yl)-2-oxazolidinone Derivatives Containing a Pyrimidine Substituted Piperazine
por: Wang, Xin, et al.
Publicado: (2023)

Antibacterial Activity of a Promising Antibacterial Agent: 22-(4-(2-(4-Nitrophenyl-piperazin-1-yl)-acetyl)-piperazin-1-yl)-22-deoxypleuromutilin
por: Zuo, Xiang-Yi, et al.
Publicado: (2021)

3-Chloro-6-[4-(2-pyridyl)piperazin-1-yl]pyridazine
por: Arslan, Hakan, et al.
Publicado: (2009)

[2-(4-Methylpiperazin-1-ylmethyl)phenyl]diphenylphosphane
por: Covaci, Ancuţa, et al.
Publicado: (2009)

(2,3-Difluorophenyl)(4-tosylpiperazin-1-yl)methanone
por: Sreenivasa, S., et al.
Publicado: (2013)

1-[4-(4-Hydroxyphenyl)piperazin-1-yl]ethanone
por: Kavitha, Channappa N., et al.
Publicado: (2013)

1-{4-[Bis(4-fluorophenyl)methyl]piperazin-1-yl}ethanone
por: Dayananda, A. S., et al.
Publicado: (2012)

2-{4-[(1,3-Benzodioxol-5-yl)methyl]piperazin-1-yl}pyrimidine
por: Wu, Chunli, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_0rgv8obaogke2aubm53ss5g7t7