A Convenient One-Pot Preparation of 2-Methyl-3-(phenylthio- methyl)quinolines from Morita-Baylis-Hillman Adducts and Their Oxidation to the Corresponding Sulfones

A convenient one-pot preparation of 2-methyl-3-(phenylthiomethyl)quinolines from Morita-Baylis-Hillman adducts via conjugate addition of thiols followed by reductive cyclization with Fe/AcOH was developed. The 2-methyl-3-(phenylthiomethyl)quinolines were transformed into 2-methyl-3-(phenylsulfonylme...

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Detalles Bibliográficos
Autores principales: Ramesh, Chintakunta, Lei, Po-Min, Kavala, Veerababurao, Kuo, Chun-Wei, Yao, Ching-Fa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268867/
https://www.ncbi.nlm.nih.gov/pubmed/22555297
http://dx.doi.org/10.3390/molecules17055081
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author Ramesh, Chintakunta
Lei, Po-Min
Kavala, Veerababurao
Kuo, Chun-Wei
Yao, Ching-Fa
author_facet Ramesh, Chintakunta
Lei, Po-Min
Kavala, Veerababurao
Kuo, Chun-Wei
Yao, Ching-Fa
author_sort Ramesh, Chintakunta
collection PubMed
description A convenient one-pot preparation of 2-methyl-3-(phenylthiomethyl)quinolines from Morita-Baylis-Hillman adducts via conjugate addition of thiols followed by reductive cyclization with Fe/AcOH was developed. The 2-methyl-3-(phenylthiomethyl)quinolines were transformed into 2-methyl-3-(phenylsulfonylmethyl)quinolines via m-CPBA-mediated oxidation.
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spelling pubmed-62688672018-12-20 A Convenient One-Pot Preparation of 2-Methyl-3-(phenylthio- methyl)quinolines from Morita-Baylis-Hillman Adducts and Their Oxidation to the Corresponding Sulfones Ramesh, Chintakunta Lei, Po-Min Kavala, Veerababurao Kuo, Chun-Wei Yao, Ching-Fa Molecules Article A convenient one-pot preparation of 2-methyl-3-(phenylthiomethyl)quinolines from Morita-Baylis-Hillman adducts via conjugate addition of thiols followed by reductive cyclization with Fe/AcOH was developed. The 2-methyl-3-(phenylthiomethyl)quinolines were transformed into 2-methyl-3-(phenylsulfonylmethyl)quinolines via m-CPBA-mediated oxidation. MDPI 2012-05-03 /pmc/articles/PMC6268867/ /pubmed/22555297 http://dx.doi.org/10.3390/molecules17055081 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Ramesh, Chintakunta
Lei, Po-Min
Kavala, Veerababurao
Kuo, Chun-Wei
Yao, Ching-Fa
A Convenient One-Pot Preparation of 2-Methyl-3-(phenylthio- methyl)quinolines from Morita-Baylis-Hillman Adducts and Their Oxidation to the Corresponding Sulfones
title A Convenient One-Pot Preparation of 2-Methyl-3-(phenylthio- methyl)quinolines from Morita-Baylis-Hillman Adducts and Their Oxidation to the Corresponding Sulfones
title_full A Convenient One-Pot Preparation of 2-Methyl-3-(phenylthio- methyl)quinolines from Morita-Baylis-Hillman Adducts and Their Oxidation to the Corresponding Sulfones
title_fullStr A Convenient One-Pot Preparation of 2-Methyl-3-(phenylthio- methyl)quinolines from Morita-Baylis-Hillman Adducts and Their Oxidation to the Corresponding Sulfones
title_full_unstemmed A Convenient One-Pot Preparation of 2-Methyl-3-(phenylthio- methyl)quinolines from Morita-Baylis-Hillman Adducts and Their Oxidation to the Corresponding Sulfones
title_short A Convenient One-Pot Preparation of 2-Methyl-3-(phenylthio- methyl)quinolines from Morita-Baylis-Hillman Adducts and Their Oxidation to the Corresponding Sulfones
title_sort convenient one-pot preparation of 2-methyl-3-(phenylthio- methyl)quinolines from morita-baylis-hillman adducts and their oxidation to the corresponding sulfones
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268867/
https://www.ncbi.nlm.nih.gov/pubmed/22555297
http://dx.doi.org/10.3390/molecules17055081
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