N-Substituted 5–Chloro-6-phenylpyridazin-3(2H)-ones: Synthesis, Insecticidal Activity Against Plutella xylostella (L.) and SAR Study

A series of N-substituted 5–chloro-6-phenylpyridazin-3(2H)-one derivatives were synthesized based on our previous work; all compounds were characterized by spectral data and tested for in vitro insecticidal activity against Plutella xylostella. The results showed that the synthesized pyridazin-3(2H)...

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Autores principales: Wu, Jian, Kang, Shenghong, Yuan, Qinkun, Luo, Lijun, Ma, Juan, Shi, Qingcai, Yang, Song
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268875/
https://www.ncbi.nlm.nih.gov/pubmed/22869161
http://dx.doi.org/10.3390/molecules17089413
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author Wu, Jian
Kang, Shenghong
Yuan, Qinkun
Luo, Lijun
Ma, Juan
Shi, Qingcai
Yang, Song
author_facet Wu, Jian
Kang, Shenghong
Yuan, Qinkun
Luo, Lijun
Ma, Juan
Shi, Qingcai
Yang, Song
author_sort Wu, Jian
collection PubMed
description A series of N-substituted 5–chloro-6-phenylpyridazin-3(2H)-one derivatives were synthesized based on our previous work; all compounds were characterized by spectral data and tested for in vitro insecticidal activity against Plutella xylostella. The results showed that the synthesized pyridazin-3(2H)-one compounds possessed good insecticidal activities, especially the compounds 4b, 4d, and 4h which showed >90% activity at 100 mg/L. The structure-activity relationships (SAR) for these compounds were also discussed.
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spelling pubmed-62688752018-12-12 N-Substituted 5–Chloro-6-phenylpyridazin-3(2H)-ones: Synthesis, Insecticidal Activity Against Plutella xylostella (L.) and SAR Study Wu, Jian Kang, Shenghong Yuan, Qinkun Luo, Lijun Ma, Juan Shi, Qingcai Yang, Song Molecules Article A series of N-substituted 5–chloro-6-phenylpyridazin-3(2H)-one derivatives were synthesized based on our previous work; all compounds were characterized by spectral data and tested for in vitro insecticidal activity against Plutella xylostella. The results showed that the synthesized pyridazin-3(2H)-one compounds possessed good insecticidal activities, especially the compounds 4b, 4d, and 4h which showed >90% activity at 100 mg/L. The structure-activity relationships (SAR) for these compounds were also discussed. MDPI 2012-08-06 /pmc/articles/PMC6268875/ /pubmed/22869161 http://dx.doi.org/10.3390/molecules17089413 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Wu, Jian
Kang, Shenghong
Yuan, Qinkun
Luo, Lijun
Ma, Juan
Shi, Qingcai
Yang, Song
N-Substituted 5–Chloro-6-phenylpyridazin-3(2H)-ones: Synthesis, Insecticidal Activity Against Plutella xylostella (L.) and SAR Study
title N-Substituted 5–Chloro-6-phenylpyridazin-3(2H)-ones: Synthesis, Insecticidal Activity Against Plutella xylostella (L.) and SAR Study
title_full N-Substituted 5–Chloro-6-phenylpyridazin-3(2H)-ones: Synthesis, Insecticidal Activity Against Plutella xylostella (L.) and SAR Study
title_fullStr N-Substituted 5–Chloro-6-phenylpyridazin-3(2H)-ones: Synthesis, Insecticidal Activity Against Plutella xylostella (L.) and SAR Study
title_full_unstemmed N-Substituted 5–Chloro-6-phenylpyridazin-3(2H)-ones: Synthesis, Insecticidal Activity Against Plutella xylostella (L.) and SAR Study
title_short N-Substituted 5–Chloro-6-phenylpyridazin-3(2H)-ones: Synthesis, Insecticidal Activity Against Plutella xylostella (L.) and SAR Study
title_sort n-substituted 5–chloro-6-phenylpyridazin-3(2h)-ones: synthesis, insecticidal activity against plutella xylostella (l.) and sar study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268875/
https://www.ncbi.nlm.nih.gov/pubmed/22869161
http://dx.doi.org/10.3390/molecules17089413
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