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3D-QSAR Studies of Dihydropyrazole and Dihydropyrrole Derivatives as Inhibitors of Human Mitotic Kinesin Eg5 Based on Molecular Docking

Human mitotic kinesin Eg5 plays an essential role in mitoses and is an interesting drug target against cancer. To find the correlation between Eg5 and its inhibitors, structure-based 3D-quantitative structure–activity relationship (QSAR) studies were performed on a series of dihydropyrazole and dihy...

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Detalles Bibliográficos
Autores principales:	Luo, Xingyan, Shu, Mao, Wang, Yuanqiang, Liu, Jin, Yang, Wenjuan, Lin, Zhihua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268882/ https://www.ncbi.nlm.nih.gov/pubmed/22343406 http://dx.doi.org/10.3390/molecules17022015

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