Three New Myrsinol Diterpenes from Euphorbia prolifera and Their Neuroprotective Activities

Three new myrsinol diterpenes were isolated from the roots of Euphorbia prolifera. Their structures were elucidated as 2α-O-isobutyryl-3β,5α,7β,10,15β-penta-O-acetyl-14α-O-benzoyl-10,18-dihydromyrsinol (1), 2α-O-isobutyryl-3β-O-propion-yl-5α,7β,10,15β-tetra-O-acetyl-10,18-dihydromyrsinol (2), and 2α...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Jing, Jin, Daqing, Guo, Ping, Xie, Chunfeng, Fang, Lingzhi, Guo, Yuanqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268895/
https://www.ncbi.nlm.nih.gov/pubmed/22878226
http://dx.doi.org/10.3390/molecules17089520
_version_ 1783376391407927296
author Xu, Jing
Jin, Daqing
Guo, Ping
Xie, Chunfeng
Fang, Lingzhi
Guo, Yuanqiang
author_facet Xu, Jing
Jin, Daqing
Guo, Ping
Xie, Chunfeng
Fang, Lingzhi
Guo, Yuanqiang
author_sort Xu, Jing
collection PubMed
description Three new myrsinol diterpenes were isolated from the roots of Euphorbia prolifera. Their structures were elucidated as 2α-O-isobutyryl-3β,5α,7β,10,15β-penta-O-acetyl-14α-O-benzoyl-10,18-dihydromyrsinol (1), 2α-O-isobutyryl-3β-O-propion-yl-5α,7β,10,15β-tetra-O-acetyl-10,18-dihydromyrsinol (2), and 2α,14α-di-O-benzoyl-3β,5α,7β,10,15β-penta-O-acetyl-10,18-dihydromyrsinol (3) on the basis of spectroscopic data analyses (IR, ESI-MS, HR-ESI-MS, and 1D and 2D NMR). Their neuroprotective activities were evaluated and compounds 1 and 2 showed neuroprotective effects against MPP(+)-induced neuronal cell death in SH-SY5Y cells.
format Online
Article
Text
id pubmed-6268895
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62688952018-12-12 Three New Myrsinol Diterpenes from Euphorbia prolifera and Their Neuroprotective Activities Xu, Jing Jin, Daqing Guo, Ping Xie, Chunfeng Fang, Lingzhi Guo, Yuanqiang Molecules Article Three new myrsinol diterpenes were isolated from the roots of Euphorbia prolifera. Their structures were elucidated as 2α-O-isobutyryl-3β,5α,7β,10,15β-penta-O-acetyl-14α-O-benzoyl-10,18-dihydromyrsinol (1), 2α-O-isobutyryl-3β-O-propion-yl-5α,7β,10,15β-tetra-O-acetyl-10,18-dihydromyrsinol (2), and 2α,14α-di-O-benzoyl-3β,5α,7β,10,15β-penta-O-acetyl-10,18-dihydromyrsinol (3) on the basis of spectroscopic data analyses (IR, ESI-MS, HR-ESI-MS, and 1D and 2D NMR). Their neuroprotective activities were evaluated and compounds 1 and 2 showed neuroprotective effects against MPP(+)-induced neuronal cell death in SH-SY5Y cells. MDPI 2012-08-09 /pmc/articles/PMC6268895/ /pubmed/22878226 http://dx.doi.org/10.3390/molecules17089520 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Xu, Jing
Jin, Daqing
Guo, Ping
Xie, Chunfeng
Fang, Lingzhi
Guo, Yuanqiang
Three New Myrsinol Diterpenes from Euphorbia prolifera and Their Neuroprotective Activities
title Three New Myrsinol Diterpenes from Euphorbia prolifera and Their Neuroprotective Activities
title_full Three New Myrsinol Diterpenes from Euphorbia prolifera and Their Neuroprotective Activities
title_fullStr Three New Myrsinol Diterpenes from Euphorbia prolifera and Their Neuroprotective Activities
title_full_unstemmed Three New Myrsinol Diterpenes from Euphorbia prolifera and Their Neuroprotective Activities
title_short Three New Myrsinol Diterpenes from Euphorbia prolifera and Their Neuroprotective Activities
title_sort three new myrsinol diterpenes from euphorbia prolifera and their neuroprotective activities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268895/
https://www.ncbi.nlm.nih.gov/pubmed/22878226
http://dx.doi.org/10.3390/molecules17089520
work_keys_str_mv AT xujing threenewmyrsinolditerpenesfromeuphorbiaproliferaandtheirneuroprotectiveactivities
AT jindaqing threenewmyrsinolditerpenesfromeuphorbiaproliferaandtheirneuroprotectiveactivities
AT guoping threenewmyrsinolditerpenesfromeuphorbiaproliferaandtheirneuroprotectiveactivities
AT xiechunfeng threenewmyrsinolditerpenesfromeuphorbiaproliferaandtheirneuroprotectiveactivities
AT fanglingzhi threenewmyrsinolditerpenesfromeuphorbiaproliferaandtheirneuroprotectiveactivities
AT guoyuanqiang threenewmyrsinolditerpenesfromeuphorbiaproliferaandtheirneuroprotectiveactivities

Ejemplares similares