Synthesis and Biological Evaluation of Novel N-Methyl-picolinamide-4-thiol Derivatives as Potential Antitumor Agents

A novel series of N-methylpicolinamide-4-thiol derivatives were synthesized and evaluated on human cancer cell lines. Among them, compound 6p displayed potent and broad-spectrum anti-proliferative activities in vitro on some human cancer cell lines, even better than sorafenib. The advanced kinase in...

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Detalles Bibliográficos
Autores principales: Huang, Ting-Ting, Huang, Yun-Chuang, Qing, Xiao- Yu, Xia, Yong, Luo, Xun, Ye, Ting-Hong, Yu, Luo-Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268926/
https://www.ncbi.nlm.nih.gov/pubmed/22634842
http://dx.doi.org/10.3390/molecules17066317

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268926/
https://www.ncbi.nlm.nih.gov/pubmed/22634842
http://dx.doi.org/10.3390/molecules17066317

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