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Acuminatol and Other Antioxidative Resveratrol Oligomers from the Stem Bark of Shorea acuminata

A new resveratrol dimer, acuminatol (1), was isolated along with five known compounds from the acetone extract of the stem bark of Shorea acuminata. Their structures and stereochemistry were determined by spectroscopic methods, which included the extensive use of 2D NMR techniques. All isolated comp...

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Autores principales: Muhammad, Norhayati, Din, Laily B., Sahidin, Idin, Hashim, Siti Farah, Ibrahim, Nazlina, Zakaria, Zuriati, Yaacob, Wan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268933/
https://www.ncbi.nlm.nih.gov/pubmed/22847143
http://dx.doi.org/10.3390/molecules17089043
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author Muhammad, Norhayati
Din, Laily B.
Sahidin, Idin
Hashim, Siti Farah
Ibrahim, Nazlina
Zakaria, Zuriati
Yaacob, Wan A.
author_facet Muhammad, Norhayati
Din, Laily B.
Sahidin, Idin
Hashim, Siti Farah
Ibrahim, Nazlina
Zakaria, Zuriati
Yaacob, Wan A.
author_sort Muhammad, Norhayati
collection PubMed
description A new resveratrol dimer, acuminatol (1), was isolated along with five known compounds from the acetone extract of the stem bark of Shorea acuminata. Their structures and stereochemistry were determined by spectroscopic methods, which included the extensive use of 2D NMR techniques. All isolated compounds were evaluated for their antioxidant activity using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity (RSA) and the β-carotene-linoleic acid (BCLA) assays, and compared with those of the standards of ascorbic acid (AscA) and butylated hydroxytoluene (BHT). All compounds tested exhibited good to moderate antioxidant activity in the DPPH assay (IC(50)s 0.84 to 10.06 mM) and displayed strong inhibition of β-carotene oxidation (IC(50)s 0.10 to 0.22 mM). The isolated compounds were evaluated on the Vero cell line and were found to be non-cytotoxic with LC(50) values between 161 to 830 µM.
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spelling pubmed-62689332018-12-12 Acuminatol and Other Antioxidative Resveratrol Oligomers from the Stem Bark of Shorea acuminata Muhammad, Norhayati Din, Laily B. Sahidin, Idin Hashim, Siti Farah Ibrahim, Nazlina Zakaria, Zuriati Yaacob, Wan A. Molecules Article A new resveratrol dimer, acuminatol (1), was isolated along with five known compounds from the acetone extract of the stem bark of Shorea acuminata. Their structures and stereochemistry were determined by spectroscopic methods, which included the extensive use of 2D NMR techniques. All isolated compounds were evaluated for their antioxidant activity using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity (RSA) and the β-carotene-linoleic acid (BCLA) assays, and compared with those of the standards of ascorbic acid (AscA) and butylated hydroxytoluene (BHT). All compounds tested exhibited good to moderate antioxidant activity in the DPPH assay (IC(50)s 0.84 to 10.06 mM) and displayed strong inhibition of β-carotene oxidation (IC(50)s 0.10 to 0.22 mM). The isolated compounds were evaluated on the Vero cell line and were found to be non-cytotoxic with LC(50) values between 161 to 830 µM. MDPI 2012-07-30 /pmc/articles/PMC6268933/ /pubmed/22847143 http://dx.doi.org/10.3390/molecules17089043 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Muhammad, Norhayati
Din, Laily B.
Sahidin, Idin
Hashim, Siti Farah
Ibrahim, Nazlina
Zakaria, Zuriati
Yaacob, Wan A.
Acuminatol and Other Antioxidative Resveratrol Oligomers from the Stem Bark of Shorea acuminata
title Acuminatol and Other Antioxidative Resveratrol Oligomers from the Stem Bark of Shorea acuminata
title_full Acuminatol and Other Antioxidative Resveratrol Oligomers from the Stem Bark of Shorea acuminata
title_fullStr Acuminatol and Other Antioxidative Resveratrol Oligomers from the Stem Bark of Shorea acuminata
title_full_unstemmed Acuminatol and Other Antioxidative Resveratrol Oligomers from the Stem Bark of Shorea acuminata
title_short Acuminatol and Other Antioxidative Resveratrol Oligomers from the Stem Bark of Shorea acuminata
title_sort acuminatol and other antioxidative resveratrol oligomers from the stem bark of shorea acuminata
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268933/
https://www.ncbi.nlm.nih.gov/pubmed/22847143
http://dx.doi.org/10.3390/molecules17089043
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