A Facile and Efficient Procedure for the Synthesis of New Benzimidazole-2-thione Derivatives

A series of benzimidazole-2-thione derivatives was synthesized using a reaction between the macrocyclic aminal 16H,13H-5:12,7:14-dimethanedibenzo[d,i]-[1,3,6,8] tetraazecine (DMDBTA, 5) and various nucleophiles in the presence of carbon disulfide. A full chemical characterization using IR, (1)H-, (1...

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Detalles Bibliográficos
Autores principales: Rivera, Augusto, Maldonado, Mauricio, Ríos-Motta, Jaime
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268960/
https://www.ncbi.nlm.nih.gov/pubmed/22805508
http://dx.doi.org/10.3390/molecules17078578
Descripción
Sumario:A series of benzimidazole-2-thione derivatives was synthesized using a reaction between the macrocyclic aminal 16H,13H-5:12,7:14-dimethanedibenzo[d,i]-[1,3,6,8] tetraazecine (DMDBTA, 5) and various nucleophiles in the presence of carbon disulfide. A full chemical characterization using IR, (1)H-, (13)C-NMR and GC-MS analyses of the new compounds is provided. These compounds were separated from the reaction mixture by column chromatography (CC) in highly pure form in 15%–51.4% yield.

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