A Facile and Efficient Procedure for the Synthesis of New Benzimidazole-2-thione Derivatives

A series of benzimidazole-2-thione derivatives was synthesized using a reaction between the macrocyclic aminal 16H,13H-5:12,7:14-dimethanedibenzo[d,i]-[1,3,6,8] tetraazecine (DMDBTA, 5) and various nucleophiles in the presence of carbon disulfide. A full chemical characterization using IR, (1)H-, (1...

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Detalles Bibliográficos
Autores principales: Rivera, Augusto, Maldonado, Mauricio, Ríos-Motta, Jaime
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268960/
https://www.ncbi.nlm.nih.gov/pubmed/22805508
http://dx.doi.org/10.3390/molecules17078578
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author Rivera, Augusto
Maldonado, Mauricio
Ríos-Motta, Jaime
author_facet Rivera, Augusto
Maldonado, Mauricio
Ríos-Motta, Jaime
author_sort Rivera, Augusto
collection PubMed
description A series of benzimidazole-2-thione derivatives was synthesized using a reaction between the macrocyclic aminal 16H,13H-5:12,7:14-dimethanedibenzo[d,i]-[1,3,6,8] tetraazecine (DMDBTA, 5) and various nucleophiles in the presence of carbon disulfide. A full chemical characterization using IR, (1)H-, (13)C-NMR and GC-MS analyses of the new compounds is provided. These compounds were separated from the reaction mixture by column chromatography (CC) in highly pure form in 15%–51.4% yield.
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spelling pubmed-62689602018-12-12 A Facile and Efficient Procedure for the Synthesis of New Benzimidazole-2-thione Derivatives Rivera, Augusto Maldonado, Mauricio Ríos-Motta, Jaime Molecules Article A series of benzimidazole-2-thione derivatives was synthesized using a reaction between the macrocyclic aminal 16H,13H-5:12,7:14-dimethanedibenzo[d,i]-[1,3,6,8] tetraazecine (DMDBTA, 5) and various nucleophiles in the presence of carbon disulfide. A full chemical characterization using IR, (1)H-, (13)C-NMR and GC-MS analyses of the new compounds is provided. These compounds were separated from the reaction mixture by column chromatography (CC) in highly pure form in 15%–51.4% yield. MDPI 2012-07-17 /pmc/articles/PMC6268960/ /pubmed/22805508 http://dx.doi.org/10.3390/molecules17078578 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Rivera, Augusto
Maldonado, Mauricio
Ríos-Motta, Jaime
A Facile and Efficient Procedure for the Synthesis of New Benzimidazole-2-thione Derivatives
title A Facile and Efficient Procedure for the Synthesis of New Benzimidazole-2-thione Derivatives
title_full A Facile and Efficient Procedure for the Synthesis of New Benzimidazole-2-thione Derivatives
title_fullStr A Facile and Efficient Procedure for the Synthesis of New Benzimidazole-2-thione Derivatives
title_full_unstemmed A Facile and Efficient Procedure for the Synthesis of New Benzimidazole-2-thione Derivatives
title_short A Facile and Efficient Procedure for the Synthesis of New Benzimidazole-2-thione Derivatives
title_sort facile and efficient procedure for the synthesis of new benzimidazole-2-thione derivatives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268960/
https://www.ncbi.nlm.nih.gov/pubmed/22805508
http://dx.doi.org/10.3390/molecules17078578
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