A Novel Antioxidant Isobenzofuranone Derivative from Fungus Cephalosporium sp.AL031

Bioassay-guided fractionation of metabolites from the fungus Cephalosporium sp.AL031 isolated from Sinarundinaria nitida led to the discovery of a new isobenzofuranone derivative, 4,6-dihydroxy-5-methoxy-7-methylphthalide (1), together with three known compounds: 4,5,6-trihydroxy-7-methyl-1,3-dihydr...

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Autores principales: Huang, Xiang-Zhong, Zhu, Yun, Guan, Xiao-Li, Tian, Kai, Guo, Jun-Ming, Wang, Hong-Bin, Fu, Guang-Miao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268973/
https://www.ncbi.nlm.nih.gov/pubmed/22481542
http://dx.doi.org/10.3390/molecules17044219
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author Huang, Xiang-Zhong
Zhu, Yun
Guan, Xiao-Li
Tian, Kai
Guo, Jun-Ming
Wang, Hong-Bin
Fu, Guang-Miao
author_facet Huang, Xiang-Zhong
Zhu, Yun
Guan, Xiao-Li
Tian, Kai
Guo, Jun-Ming
Wang, Hong-Bin
Fu, Guang-Miao
author_sort Huang, Xiang-Zhong
collection PubMed
description Bioassay-guided fractionation of metabolites from the fungus Cephalosporium sp.AL031 isolated from Sinarundinaria nitida led to the discovery of a new isobenzofuranone derivative, 4,6-dihydroxy-5-methoxy-7-methylphthalide (1), together with three known compounds: 4,5,6-trihydroxy-7-methyl-1,3-dihydroisobenzofuran (2), 4,6-dihydroxy-5-methoxy-7-methyl-1,3-dihydroisobenzofuran (3) and 4,5,6-trihydroxy-7-methylphthalide (4). The structure of the new compound 1 was determined based on MS, 1D and 2D NMR spectral data. Compounds 1–4 showed potent antioxidant activity with EC(50) values of 10, 7, 22 and 5 μM by 1,1-diphenyl-2-picryhydrazyl (DPPH) radical-scavenging assay.
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spelling pubmed-62689732018-12-11 A Novel Antioxidant Isobenzofuranone Derivative from Fungus Cephalosporium sp.AL031 Huang, Xiang-Zhong Zhu, Yun Guan, Xiao-Li Tian, Kai Guo, Jun-Ming Wang, Hong-Bin Fu, Guang-Miao Molecules Article Bioassay-guided fractionation of metabolites from the fungus Cephalosporium sp.AL031 isolated from Sinarundinaria nitida led to the discovery of a new isobenzofuranone derivative, 4,6-dihydroxy-5-methoxy-7-methylphthalide (1), together with three known compounds: 4,5,6-trihydroxy-7-methyl-1,3-dihydroisobenzofuran (2), 4,6-dihydroxy-5-methoxy-7-methyl-1,3-dihydroisobenzofuran (3) and 4,5,6-trihydroxy-7-methylphthalide (4). The structure of the new compound 1 was determined based on MS, 1D and 2D NMR spectral data. Compounds 1–4 showed potent antioxidant activity with EC(50) values of 10, 7, 22 and 5 μM by 1,1-diphenyl-2-picryhydrazyl (DPPH) radical-scavenging assay. MDPI 2012-04-05 /pmc/articles/PMC6268973/ /pubmed/22481542 http://dx.doi.org/10.3390/molecules17044219 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Huang, Xiang-Zhong
Zhu, Yun
Guan, Xiao-Li
Tian, Kai
Guo, Jun-Ming
Wang, Hong-Bin
Fu, Guang-Miao
A Novel Antioxidant Isobenzofuranone Derivative from Fungus Cephalosporium sp.AL031
title A Novel Antioxidant Isobenzofuranone Derivative from Fungus Cephalosporium sp.AL031
title_full A Novel Antioxidant Isobenzofuranone Derivative from Fungus Cephalosporium sp.AL031
title_fullStr A Novel Antioxidant Isobenzofuranone Derivative from Fungus Cephalosporium sp.AL031
title_full_unstemmed A Novel Antioxidant Isobenzofuranone Derivative from Fungus Cephalosporium sp.AL031
title_short A Novel Antioxidant Isobenzofuranone Derivative from Fungus Cephalosporium sp.AL031
title_sort novel antioxidant isobenzofuranone derivative from fungus cephalosporium sp.al031
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268973/
https://www.ncbi.nlm.nih.gov/pubmed/22481542
http://dx.doi.org/10.3390/molecules17044219
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