An ent-Kaurane-Type Diterpene in Croton antisyphiliticus Mart.

Croton antisyphiliticus is a medicinal plant widely used in the treatment of microbial infections, especially those affecting the genital tract. Crude extract, fractions and pure compound isolated from roots of this species were investigated to validate their antimicrobial activity against Escherich...

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Detalles Bibliográficos
Autores principales: Pereira, Sarazete, Taleb-Contini, Silvia, Coppede, Juliana, Pereira, Paulo, Bertoni, Bianca, França, Suzelei, Pereira, Ana Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268975/
https://www.ncbi.nlm.nih.gov/pubmed/22832886
http://dx.doi.org/10.3390/molecules17088851
Descripción
Sumario:Croton antisyphiliticus is a medicinal plant widely used in the treatment of microbial infections, especially those affecting the genital tract. Crude extract, fractions and pure compound isolated from roots of this species were investigated to validate their antimicrobial activity against Escherichia coli and Staphylococcus aureus. The compound ent-kaur-16-en-18-oic acid was isolated as a major component (0.7% of crude extract), and its MIC value determined against S. aureus (ATCC 6538) was 250 μg/mL. This is the first phytochemical work on the species monitored with antimicrobial assay.

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