An Efficient Synthesis of Novel Dispirooxindole Derivatives via One-Pot Three-Component 1,3-Dipolar Cycloaddition Reactions

A series of novel dispirooxindoles have been synthesized through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and an α-amino acid with the dipolarophile 5-benzylidene-1,3-dimethylpyrimidine-2,4,6-trione. This method ha...

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Autores principales: Huang, Zhibin, Zhao, Qian, Chen, Gang, Wang, Huiyuan, Lin, Wei, Xu, Lexing, Liu, Hongtao, Wang, Juxian, Shi, Daqing, Wang, Yucheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269013/
https://www.ncbi.nlm.nih.gov/pubmed/23103534
http://dx.doi.org/10.3390/molecules171112704
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author Huang, Zhibin
Zhao, Qian
Chen, Gang
Wang, Huiyuan
Lin, Wei
Xu, Lexing
Liu, Hongtao
Wang, Juxian
Shi, Daqing
Wang, Yucheng
author_facet Huang, Zhibin
Zhao, Qian
Chen, Gang
Wang, Huiyuan
Lin, Wei
Xu, Lexing
Liu, Hongtao
Wang, Juxian
Shi, Daqing
Wang, Yucheng
author_sort Huang, Zhibin
collection PubMed
description A series of novel dispirooxindoles have been synthesized through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and an α-amino acid with the dipolarophile 5-benzylidene-1,3-dimethylpyrimidine-2,4,6-trione. This method has the advantages of mild reaction conditions, high atom economy, excellent yields, and high regio- and stereo-selectivity.
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spelling pubmed-62690132018-12-13 An Efficient Synthesis of Novel Dispirooxindole Derivatives via One-Pot Three-Component 1,3-Dipolar Cycloaddition Reactions Huang, Zhibin Zhao, Qian Chen, Gang Wang, Huiyuan Lin, Wei Xu, Lexing Liu, Hongtao Wang, Juxian Shi, Daqing Wang, Yucheng Molecules Article A series of novel dispirooxindoles have been synthesized through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and an α-amino acid with the dipolarophile 5-benzylidene-1,3-dimethylpyrimidine-2,4,6-trione. This method has the advantages of mild reaction conditions, high atom economy, excellent yields, and high regio- and stereo-selectivity. MDPI 2012-10-26 /pmc/articles/PMC6269013/ /pubmed/23103534 http://dx.doi.org/10.3390/molecules171112704 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Huang, Zhibin
Zhao, Qian
Chen, Gang
Wang, Huiyuan
Lin, Wei
Xu, Lexing
Liu, Hongtao
Wang, Juxian
Shi, Daqing
Wang, Yucheng
An Efficient Synthesis of Novel Dispirooxindole Derivatives via One-Pot Three-Component 1,3-Dipolar Cycloaddition Reactions
title An Efficient Synthesis of Novel Dispirooxindole Derivatives via One-Pot Three-Component 1,3-Dipolar Cycloaddition Reactions
title_full An Efficient Synthesis of Novel Dispirooxindole Derivatives via One-Pot Three-Component 1,3-Dipolar Cycloaddition Reactions
title_fullStr An Efficient Synthesis of Novel Dispirooxindole Derivatives via One-Pot Three-Component 1,3-Dipolar Cycloaddition Reactions
title_full_unstemmed An Efficient Synthesis of Novel Dispirooxindole Derivatives via One-Pot Three-Component 1,3-Dipolar Cycloaddition Reactions
title_short An Efficient Synthesis of Novel Dispirooxindole Derivatives via One-Pot Three-Component 1,3-Dipolar Cycloaddition Reactions
title_sort efficient synthesis of novel dispirooxindole derivatives via one-pot three-component 1,3-dipolar cycloaddition reactions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269013/
https://www.ncbi.nlm.nih.gov/pubmed/23103534
http://dx.doi.org/10.3390/molecules171112704
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