Cargando…

Practical Synthesis of Hydroxychromenes and Evaluation of Their Biological Activity

A simple and efficient seven steps synthesis of brodifacoum and difethialone from phenylacetyl chloride is described. The key synthetic strategies involve Friedel-Crafts acylation, intramolecular ring cyclization and condensation reaction in the presence of Brønsted-Lowry acids. It was found that br...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jung, Jae-Chul, Oh, Seikwan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269019/ https://www.ncbi.nlm.nih.gov/pubmed/22205090 http://dx.doi.org/10.3390/molecules17010240

Ejemplares similares

Practical Synthesis of Chalcone Derivatives and Their Biological Activities
por: Jung, Jae-Chul, et al.
Publicado: (2017)

3-Anilinothiocarbonyl-4-hydroxychromen-2-one
por: Kant, Rajni, et al.
Publicado: (2009)

Convenient Synthesis and Biological Evaluation of Modafinil Derivatives: Benzhydrylsulfanyl and Benzhydrylsulfinyl [1,2,3]triazol-4-yl-methyl Esters
por: Jung, Jae-Chul, et al.
Publicado: (2011)

Simple Synthesis of Modafinil Derivatives and Their Anti-inflammatory Activity
por: Jung, Jae-Chul, et al.
Publicado: (2012)

Exploration of multi‐target effects of 3‐benzoyl‐5‐hydroxychromen‐2‐one in Alzheimer’s disease cell and mouse models
por: Lin, Te‐Hsien, et al.
Publicado: (2020)

Anti-Inflammatory Activities of Licorice Extract and Its Active Compounds, Glycyrrhizic Acid, Liquiritin and Liquiritigenin, in BV2 Cells and Mice Liver
por: Yu, Ji-Yeon, et al.
Publicado: (2015)

Chrysanthemum morifolium and Its Bioactive Substance Enhanced the Sleep Quality in Rodent Models via Cl(−) Channel Activation
por: Kim, Mijin, et al.
Publicado: (2023)

Expeditious Entry to Novel 2-Methylene-2,3-dihydrofuro[3,2-c]chromen-2-ones from 6-Chloro-4-hydroxychromen-2-one and Propargylic Alcohols
por: Nebra, Noel, et al.
Publicado: (2011)

The Pharmacology of Actoprotectors: Practical Application for Improvement of Mental and Physical Performance
por: Oliynyk, Sergiy, et al.
Publicado: (2012)

Phytoceramide Shows Neuroprotection and Ameliorates Scopolamine-Induced Memory Impairment
por: Jung, Jae-Chul, et al.
Publicado: (2011)

Anti-Inflammatory Effect of Triterpene Saponins Isolated from Blue Cohosh (Caulophyllum thalictroides)
por: Lee, Yeonju, et al.
Publicado: (2012)

Administration of Glucosylceramide Ameliorated the Memory Impairment in Aged Mice
por: Lee, Yeonju, et al.
Publicado: (2013)

Anti-Inflammatory and Neuroprotective Effects of Constituents Isolated from Rhodiola rosea
por: Lee, Yeonju, et al.
Publicado: (2013)

Administration of Alpha(s1)-Casein Hydrolysate Increases Sleep and Modulates GABA(A) Receptor Subunit Expression
por: Yayeh, Taddesse, et al.
Publicado: (2018)

Synthesis and Biological Evaluation of BODIPY-PF-543
por: Shrestha, Jitendra, et al.
Publicado: (2019)

Hepatoprotective effect of licorice, the root of Glycyrrhiza uralensis Fischer, in alcohol-induced fatty liver disease
por: Jung, Jae-Chul, et al.
Publicado: (2016)

Actoprotective effect of ginseng: improving mental and physical performance
por: Oliynyk, Sergiy, et al.
Publicado: (2013)

Synthesis and Evaluation of Biological Activity of New Arylphosphoramidates
por: Thebti, Amal, et al.
Publicado: (2018)

Administration of red ginseng ameliorates memory decline in aged mice
por: Lee, Yeonju, et al.
Publicado: (2015)

Benzylideneacetophenone derivatives attenuate IFN-γ-induced IP-10/CXCL10 production in orbital fibroblasts of patients with thyroid-associated ophthalmopathy through STAT-1 inhibition
por: Lee, Sung-Hee, et al.
Publicado: (2014)

Korean Red Ginseng prevents posttraumatic stress disorder–triggered depression-like behaviors in rats via activation of the serotonergic system
por: Lee, Bombi, et al.
Publicado: (2020)

Bicyclic Isoxazoline Derivatives: Synthesis and Evaluation of Biological Activity
por: Sedenkova, Kseniya N., et al.
Publicado: (2022)

Fangchinoline Has an Anti-Arthritic Effect in Two Animal Models and in IL-1β-Stimulated Human FLS Cells
por: Villa, Thea, et al.
Publicado: (2020)

Neuroprotective effect of Korean Red Ginseng against single prolonged stress-induced memory impairments and inflammation in the rat brain associated with BDNF expression
por: Lee, Bombi, et al.
Publicado: (2022)

Synthesis and Biological Evaluation of Carbocyclic Analogues of Pachastrissamine
por: Kwon, Yongseok, et al.
Publicado: (2015)

Enantioselective Synthesis of Spliceostatin E and Evaluation of Biological Activity
por: Ghosh, Arun K., et al.
Publicado: (2014)

Korean Red Ginseng mitigates spinal demyelination in a model of acute multiple sclerosis by downregulating p38 mitogen-activated protein kinase and nuclear factor-κB signaling pathways
por: Lee, Min Jung, et al.
Publicado: (2018)

Synthetic Approaches and Biological Activities of 4-Hydroxycoumarin Derivatives
por: Jung, Jae-Chul, et al.
Publicado: (2009)

Synthesis of umbelliferone derivatives in Escherichia coli and their biological activities
por: Chu, Luan Luong, et al.
Publicado: (2017)

Synthesis and Evaluation of Biological Activities of Aziridine Derivatives of Urea and Thiourea
por: Kowalczyk, Aleksandra, et al.
Publicado: (2017)

Synthesis and Biological Activity Evaluation of Novel Heterocyclic Pleuromutilin Derivatives
por: Yi, Yunpeng, et al.
Publicado: (2017)

Synthesis and Biological Activity Evaluation of Coumarin-3-Carboxamide Derivatives
por: Phutdhawong, Weerachai, et al.
Publicado: (2021)

Design, synthesis, and biological evaluation of tetrahydroquinolinones and tetrahydroquinolines with anticancer activity
por: Ryczkowska, Małgorzata, et al.
Publicado: (2022)

Synthesis and Biological Evaluation of Novel Dispiro-Indolinones with Anticancer Activity
por: Ivanenkov, Yan A., et al.
Publicado: (2023)

BPA‐toxicity via superoxide anion overload and a deficit in β‐catenin signaling in human bone mesenchymal stem cells
por: Leem, Yea‐Hyun, et al.
Publicado: (2016)

Synthesis of Some Novel Chromenopyrimidine Derivatives and Evaluation of Their Biological Activities
por: Mobinikhaledi, Akbar, et al.
Publicado: (2014)

Inhibitory activity of gintonin on inflammation in human IL-1β-stimulated fibroblast-like synoviocytes and collagen-induced arthritis in mice
por: Kim, Mijin, et al.
Publicado: (2021)

Chemo-enzymatic synthesis and biological activity evaluation of propenylbenzene derivatives
por: Hernik, Dawid, et al.
Publicado: (2023)

Synthesis of novel phytol-derived γ-butyrolactones and evaluation of their biological activity
por: Gliszczyńska, Anna, et al.
Publicado: (2021)

Synthesis, Characterization, and Biological Evaluation of Tetrahydropyrimidines: Dual-Activity and Mechanism of Action
por: Milović, Emilija, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_g2phh77sv3ke1n87mk8479iniu