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Design, Synthesis and Anti-fibrosis Activity Study of N(1)-Substituted Phenylhydroquinolinone Derivatives

Pirfenidone (5-methyl-1-phenyl-2(1H)-pyridone, PFD) is a small-molecule compound acting on multiple targets involved in pathological fibrogenesis and is effective to increase the survival of patients with fibrosis, such as idiopathic pulmonary fibrosis. However, PFD is not active enough, requiring a...

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Detalles Bibliográficos
Autores principales:	Wu, Ling, Liu, Bin, Li, Qianbin, Chen, Jun, Tao, Lijian, Hu, Gaoyun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269057/ https://www.ncbi.nlm.nih.gov/pubmed/22301723 http://dx.doi.org/10.3390/molecules17021373

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