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Short and Long-Term Effects of Baccharis articulata on Glucose Homeostasis
In this study, the in vivo effect of the crude extract and n-butanol and aqueous residual fractions of Baccharis articulata (Lam.) Pers. on serum glucose levels, insulin secretion and liver and muscle glycogen content, as well as in vitro action on serum intestinal disaccharidase activity and albumi...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269064/ https://www.ncbi.nlm.nih.gov/pubmed/22664465 http://dx.doi.org/10.3390/molecules17066754 |
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author | Kappel, Virginia D. Pereira, Danielle F. Cazarolli, Luisa H. Guesser, Samantha M. da Silva, Carlos H. Blum Schenkel, Eloir P. Reginatto, Flávio H. Silva, Fátima R. M. B. |
author_facet | Kappel, Virginia D. Pereira, Danielle F. Cazarolli, Luisa H. Guesser, Samantha M. da Silva, Carlos H. Blum Schenkel, Eloir P. Reginatto, Flávio H. Silva, Fátima R. M. B. |
author_sort | Kappel, Virginia D. |
collection | PubMed |
description | In this study, the in vivo effect of the crude extract and n-butanol and aqueous residual fractions of Baccharis articulata (Lam.) Pers. on serum glucose levels, insulin secretion and liver and muscle glycogen content, as well as in vitro action on serum intestinal disaccharidase activity and albumin glycation were investigated. Oral administration of the extract and fractions reduced glycemia in hyperglycemic rats. Additionally, the n-butanol fraction, which has high flavonoids content, stimulated insulin secretion, exhibiting an insulinogenic index similar to that of glipizide. Also, the n-butanol fraction treatment significantly increased glycogen content in both liver and muscle tissue. In vitro incubation with the crude extract and n-butanol and aqueous residual fractions inhibited maltase activity and the formation of advanced glycation end-products (AGEs). Thus, the results demonstrated that B. articulata exhibits a significant antihyperglycemic and insulin-secretagogue role. These effects on the regulation of glucose homeostasis observed for B. articulata indicate potential anti-diabetic properties. |
format | Online Article Text |
id | pubmed-6269064 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62690642018-12-12 Short and Long-Term Effects of Baccharis articulata on Glucose Homeostasis Kappel, Virginia D. Pereira, Danielle F. Cazarolli, Luisa H. Guesser, Samantha M. da Silva, Carlos H. Blum Schenkel, Eloir P. Reginatto, Flávio H. Silva, Fátima R. M. B. Molecules Article In this study, the in vivo effect of the crude extract and n-butanol and aqueous residual fractions of Baccharis articulata (Lam.) Pers. on serum glucose levels, insulin secretion and liver and muscle glycogen content, as well as in vitro action on serum intestinal disaccharidase activity and albumin glycation were investigated. Oral administration of the extract and fractions reduced glycemia in hyperglycemic rats. Additionally, the n-butanol fraction, which has high flavonoids content, stimulated insulin secretion, exhibiting an insulinogenic index similar to that of glipizide. Also, the n-butanol fraction treatment significantly increased glycogen content in both liver and muscle tissue. In vitro incubation with the crude extract and n-butanol and aqueous residual fractions inhibited maltase activity and the formation of advanced glycation end-products (AGEs). Thus, the results demonstrated that B. articulata exhibits a significant antihyperglycemic and insulin-secretagogue role. These effects on the regulation of glucose homeostasis observed for B. articulata indicate potential anti-diabetic properties. MDPI 2012-06-04 /pmc/articles/PMC6269064/ /pubmed/22664465 http://dx.doi.org/10.3390/molecules17066754 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Kappel, Virginia D. Pereira, Danielle F. Cazarolli, Luisa H. Guesser, Samantha M. da Silva, Carlos H. Blum Schenkel, Eloir P. Reginatto, Flávio H. Silva, Fátima R. M. B. Short and Long-Term Effects of Baccharis articulata on Glucose Homeostasis |
title | Short and Long-Term Effects of Baccharis articulata on Glucose Homeostasis |
title_full | Short and Long-Term Effects of Baccharis articulata on Glucose Homeostasis |
title_fullStr | Short and Long-Term Effects of Baccharis articulata on Glucose Homeostasis |
title_full_unstemmed | Short and Long-Term Effects of Baccharis articulata on Glucose Homeostasis |
title_short | Short and Long-Term Effects of Baccharis articulata on Glucose Homeostasis |
title_sort | short and long-term effects of baccharis articulata on glucose homeostasis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269064/ https://www.ncbi.nlm.nih.gov/pubmed/22664465 http://dx.doi.org/10.3390/molecules17066754 |
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