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Short and Long-Term Effects of Baccharis articulata on Glucose Homeostasis

In this study, the in vivo effect of the crude extract and n-butanol and aqueous residual fractions of Baccharis articulata (Lam.) Pers. on serum glucose levels, insulin secretion and liver and muscle glycogen content, as well as in vitro action on serum intestinal disaccharidase activity and albumi...

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Autores principales: Kappel, Virginia D., Pereira, Danielle F., Cazarolli, Luisa H., Guesser, Samantha M., da Silva, Carlos H. Blum, Schenkel, Eloir P., Reginatto, Flávio H., Silva, Fátima R. M. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269064/
https://www.ncbi.nlm.nih.gov/pubmed/22664465
http://dx.doi.org/10.3390/molecules17066754
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author Kappel, Virginia D.
Pereira, Danielle F.
Cazarolli, Luisa H.
Guesser, Samantha M.
da Silva, Carlos H. Blum
Schenkel, Eloir P.
Reginatto, Flávio H.
Silva, Fátima R. M. B.
author_facet Kappel, Virginia D.
Pereira, Danielle F.
Cazarolli, Luisa H.
Guesser, Samantha M.
da Silva, Carlos H. Blum
Schenkel, Eloir P.
Reginatto, Flávio H.
Silva, Fátima R. M. B.
author_sort Kappel, Virginia D.
collection PubMed
description In this study, the in vivo effect of the crude extract and n-butanol and aqueous residual fractions of Baccharis articulata (Lam.) Pers. on serum glucose levels, insulin secretion and liver and muscle glycogen content, as well as in vitro action on serum intestinal disaccharidase activity and albumin glycation were investigated. Oral administration of the extract and fractions reduced glycemia in hyperglycemic rats. Additionally, the n-butanol fraction, which has high flavonoids content, stimulated insulin secretion, exhibiting an insulinogenic index similar to that of glipizide. Also, the n-butanol fraction treatment significantly increased glycogen content in both liver and muscle tissue. In vitro incubation with the crude extract and n-butanol and aqueous residual fractions inhibited maltase activity and the formation of advanced glycation end-products (AGEs). Thus, the results demonstrated that B. articulata exhibits a significant antihyperglycemic and insulin-secretagogue role. These effects on the regulation of glucose homeostasis observed for B. articulata indicate potential anti-diabetic properties.
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spelling pubmed-62690642018-12-12 Short and Long-Term Effects of Baccharis articulata on Glucose Homeostasis Kappel, Virginia D. Pereira, Danielle F. Cazarolli, Luisa H. Guesser, Samantha M. da Silva, Carlos H. Blum Schenkel, Eloir P. Reginatto, Flávio H. Silva, Fátima R. M. B. Molecules Article In this study, the in vivo effect of the crude extract and n-butanol and aqueous residual fractions of Baccharis articulata (Lam.) Pers. on serum glucose levels, insulin secretion and liver and muscle glycogen content, as well as in vitro action on serum intestinal disaccharidase activity and albumin glycation were investigated. Oral administration of the extract and fractions reduced glycemia in hyperglycemic rats. Additionally, the n-butanol fraction, which has high flavonoids content, stimulated insulin secretion, exhibiting an insulinogenic index similar to that of glipizide. Also, the n-butanol fraction treatment significantly increased glycogen content in both liver and muscle tissue. In vitro incubation with the crude extract and n-butanol and aqueous residual fractions inhibited maltase activity and the formation of advanced glycation end-products (AGEs). Thus, the results demonstrated that B. articulata exhibits a significant antihyperglycemic and insulin-secretagogue role. These effects on the regulation of glucose homeostasis observed for B. articulata indicate potential anti-diabetic properties. MDPI 2012-06-04 /pmc/articles/PMC6269064/ /pubmed/22664465 http://dx.doi.org/10.3390/molecules17066754 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Kappel, Virginia D.
Pereira, Danielle F.
Cazarolli, Luisa H.
Guesser, Samantha M.
da Silva, Carlos H. Blum
Schenkel, Eloir P.
Reginatto, Flávio H.
Silva, Fátima R. M. B.
Short and Long-Term Effects of Baccharis articulata on Glucose Homeostasis
title Short and Long-Term Effects of Baccharis articulata on Glucose Homeostasis
title_full Short and Long-Term Effects of Baccharis articulata on Glucose Homeostasis
title_fullStr Short and Long-Term Effects of Baccharis articulata on Glucose Homeostasis
title_full_unstemmed Short and Long-Term Effects of Baccharis articulata on Glucose Homeostasis
title_short Short and Long-Term Effects of Baccharis articulata on Glucose Homeostasis
title_sort short and long-term effects of baccharis articulata on glucose homeostasis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269064/
https://www.ncbi.nlm.nih.gov/pubmed/22664465
http://dx.doi.org/10.3390/molecules17066754
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