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New Quinoxaline Derivatives as Potential MT(1) and MT(2) Receptor Ligands

Ever since the idea arose that melatonin might promote sleep and resynchronize circadian rhythms, many research groups have centered their efforts on obtaining new melatonin receptor ligands whose pharmacophores include an aliphatic chain of variable length united to an N-alkylamide and a methoxy gr...

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Detalles Bibliográficos
Autores principales: Ancizu, Saioa, Castrillo, Nerea, Pérez-Silanes, Silvia, Aldana, Ignacio, Monge, Antonio, Delagrange, Philippe, Caignard, Daniel-Henry, Galiano, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269071/
https://www.ncbi.nlm.nih.gov/pubmed/22732886
http://dx.doi.org/10.3390/molecules17077737
Descripción
Sumario:Ever since the idea arose that melatonin might promote sleep and resynchronize circadian rhythms, many research groups have centered their efforts on obtaining new melatonin receptor ligands whose pharmacophores include an aliphatic chain of variable length united to an N-alkylamide and a methoxy group (or a bioisostere), linked to a central ring. Substitution of the indole ring found in melatonin with a naphthalene or quinoline ring leads to compounds of similar affinity. The next step in this structural approximation is to introduce a quinoxaline ring (a bioisostere of the quinoline and naphthalene rings) as the central nucleus of future melatoninergic ligands.