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New Quinoxaline Derivatives as Potential MT(1) and MT(2) Receptor Ligands

Ever since the idea arose that melatonin might promote sleep and resynchronize circadian rhythms, many research groups have centered their efforts on obtaining new melatonin receptor ligands whose pharmacophores include an aliphatic chain of variable length united to an N-alkylamide and a methoxy gr...

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Detalles Bibliográficos
Autores principales: Ancizu, Saioa, Castrillo, Nerea, Pérez-Silanes, Silvia, Aldana, Ignacio, Monge, Antonio, Delagrange, Philippe, Caignard, Daniel-Henry, Galiano, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269071/
https://www.ncbi.nlm.nih.gov/pubmed/22732886
http://dx.doi.org/10.3390/molecules17077737
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author Ancizu, Saioa
Castrillo, Nerea
Pérez-Silanes, Silvia
Aldana, Ignacio
Monge, Antonio
Delagrange, Philippe
Caignard, Daniel-Henry
Galiano, Silvia
author_facet Ancizu, Saioa
Castrillo, Nerea
Pérez-Silanes, Silvia
Aldana, Ignacio
Monge, Antonio
Delagrange, Philippe
Caignard, Daniel-Henry
Galiano, Silvia
author_sort Ancizu, Saioa
collection PubMed
description Ever since the idea arose that melatonin might promote sleep and resynchronize circadian rhythms, many research groups have centered their efforts on obtaining new melatonin receptor ligands whose pharmacophores include an aliphatic chain of variable length united to an N-alkylamide and a methoxy group (or a bioisostere), linked to a central ring. Substitution of the indole ring found in melatonin with a naphthalene or quinoline ring leads to compounds of similar affinity. The next step in this structural approximation is to introduce a quinoxaline ring (a bioisostere of the quinoline and naphthalene rings) as the central nucleus of future melatoninergic ligands.
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spelling pubmed-62690712018-12-12 New Quinoxaline Derivatives as Potential MT(1) and MT(2) Receptor Ligands Ancizu, Saioa Castrillo, Nerea Pérez-Silanes, Silvia Aldana, Ignacio Monge, Antonio Delagrange, Philippe Caignard, Daniel-Henry Galiano, Silvia Molecules Article Ever since the idea arose that melatonin might promote sleep and resynchronize circadian rhythms, many research groups have centered their efforts on obtaining new melatonin receptor ligands whose pharmacophores include an aliphatic chain of variable length united to an N-alkylamide and a methoxy group (or a bioisostere), linked to a central ring. Substitution of the indole ring found in melatonin with a naphthalene or quinoline ring leads to compounds of similar affinity. The next step in this structural approximation is to introduce a quinoxaline ring (a bioisostere of the quinoline and naphthalene rings) as the central nucleus of future melatoninergic ligands. MDPI 2012-06-25 /pmc/articles/PMC6269071/ /pubmed/22732886 http://dx.doi.org/10.3390/molecules17077737 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Ancizu, Saioa
Castrillo, Nerea
Pérez-Silanes, Silvia
Aldana, Ignacio
Monge, Antonio
Delagrange, Philippe
Caignard, Daniel-Henry
Galiano, Silvia
New Quinoxaline Derivatives as Potential MT(1) and MT(2) Receptor Ligands
title New Quinoxaline Derivatives as Potential MT(1) and MT(2) Receptor Ligands
title_full New Quinoxaline Derivatives as Potential MT(1) and MT(2) Receptor Ligands
title_fullStr New Quinoxaline Derivatives as Potential MT(1) and MT(2) Receptor Ligands
title_full_unstemmed New Quinoxaline Derivatives as Potential MT(1) and MT(2) Receptor Ligands
title_short New Quinoxaline Derivatives as Potential MT(1) and MT(2) Receptor Ligands
title_sort new quinoxaline derivatives as potential mt(1) and mt(2) receptor ligands
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269071/
https://www.ncbi.nlm.nih.gov/pubmed/22732886
http://dx.doi.org/10.3390/molecules17077737
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