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Design and Synthesis of a Novel Ganglioside Ligand for Influenza A Viruses (†)

A novel ganglioside bearing Neuα2-3Gal and Neuα2-6Gal structures as distal sequences was designed as a ligand for influenza A viruses. The efficient synthesis of the designed ganglioside was accomplished by employing the cassette coupling approach as a key reaction, which was executed between the no...

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Autores principales: Nohara, Tomohiro, Imamura, Akihiro, Yamaguchi, Maho, Hidari, Kazuya I. P. J., Suzuki, Takashi, Komori, Tatsuya, Ando, Hiromune, Ishida, Hideharu, Kiso, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269081/
https://www.ncbi.nlm.nih.gov/pubmed/22885358
http://dx.doi.org/10.3390/molecules17089590
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author Nohara, Tomohiro
Imamura, Akihiro
Yamaguchi, Maho
Hidari, Kazuya I. P. J.
Suzuki, Takashi
Komori, Tatsuya
Ando, Hiromune
Ishida, Hideharu
Kiso, Makoto
author_facet Nohara, Tomohiro
Imamura, Akihiro
Yamaguchi, Maho
Hidari, Kazuya I. P. J.
Suzuki, Takashi
Komori, Tatsuya
Ando, Hiromune
Ishida, Hideharu
Kiso, Makoto
author_sort Nohara, Tomohiro
collection PubMed
description A novel ganglioside bearing Neuα2-3Gal and Neuα2-6Gal structures as distal sequences was designed as a ligand for influenza A viruses. The efficient synthesis of the designed ganglioside was accomplished by employing the cassette coupling approach as a key reaction, which was executed between the non-reducing end of the oligosaccharide and the cyclic glucosylceramide moiety. Examination of its binding activity to influenza A viruses revealed that the new ligand is recognized by Neuα2-3 and 2-6 type viruses.
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spelling pubmed-62690812018-12-12 Design and Synthesis of a Novel Ganglioside Ligand for Influenza A Viruses (†) Nohara, Tomohiro Imamura, Akihiro Yamaguchi, Maho Hidari, Kazuya I. P. J. Suzuki, Takashi Komori, Tatsuya Ando, Hiromune Ishida, Hideharu Kiso, Makoto Molecules Article A novel ganglioside bearing Neuα2-3Gal and Neuα2-6Gal structures as distal sequences was designed as a ligand for influenza A viruses. The efficient synthesis of the designed ganglioside was accomplished by employing the cassette coupling approach as a key reaction, which was executed between the non-reducing end of the oligosaccharide and the cyclic glucosylceramide moiety. Examination of its binding activity to influenza A viruses revealed that the new ligand is recognized by Neuα2-3 and 2-6 type viruses. MDPI 2012-08-10 /pmc/articles/PMC6269081/ /pubmed/22885358 http://dx.doi.org/10.3390/molecules17089590 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Nohara, Tomohiro
Imamura, Akihiro
Yamaguchi, Maho
Hidari, Kazuya I. P. J.
Suzuki, Takashi
Komori, Tatsuya
Ando, Hiromune
Ishida, Hideharu
Kiso, Makoto
Design and Synthesis of a Novel Ganglioside Ligand for Influenza A Viruses (†)
title Design and Synthesis of a Novel Ganglioside Ligand for Influenza A Viruses (†)
title_full Design and Synthesis of a Novel Ganglioside Ligand for Influenza A Viruses (†)
title_fullStr Design and Synthesis of a Novel Ganglioside Ligand for Influenza A Viruses (†)
title_full_unstemmed Design and Synthesis of a Novel Ganglioside Ligand for Influenza A Viruses (†)
title_short Design and Synthesis of a Novel Ganglioside Ligand for Influenza A Viruses (†)
title_sort design and synthesis of a novel ganglioside ligand for influenza a viruses (†)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269081/
https://www.ncbi.nlm.nih.gov/pubmed/22885358
http://dx.doi.org/10.3390/molecules17089590
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