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Design and Synthesis of a Novel Ganglioside Ligand for Influenza A Viruses (†)
A novel ganglioside bearing Neuα2-3Gal and Neuα2-6Gal structures as distal sequences was designed as a ligand for influenza A viruses. The efficient synthesis of the designed ganglioside was accomplished by employing the cassette coupling approach as a key reaction, which was executed between the no...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269081/ https://www.ncbi.nlm.nih.gov/pubmed/22885358 http://dx.doi.org/10.3390/molecules17089590 |
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author | Nohara, Tomohiro Imamura, Akihiro Yamaguchi, Maho Hidari, Kazuya I. P. J. Suzuki, Takashi Komori, Tatsuya Ando, Hiromune Ishida, Hideharu Kiso, Makoto |
author_facet | Nohara, Tomohiro Imamura, Akihiro Yamaguchi, Maho Hidari, Kazuya I. P. J. Suzuki, Takashi Komori, Tatsuya Ando, Hiromune Ishida, Hideharu Kiso, Makoto |
author_sort | Nohara, Tomohiro |
collection | PubMed |
description | A novel ganglioside bearing Neuα2-3Gal and Neuα2-6Gal structures as distal sequences was designed as a ligand for influenza A viruses. The efficient synthesis of the designed ganglioside was accomplished by employing the cassette coupling approach as a key reaction, which was executed between the non-reducing end of the oligosaccharide and the cyclic glucosylceramide moiety. Examination of its binding activity to influenza A viruses revealed that the new ligand is recognized by Neuα2-3 and 2-6 type viruses. |
format | Online Article Text |
id | pubmed-6269081 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62690812018-12-12 Design and Synthesis of a Novel Ganglioside Ligand for Influenza A Viruses (†) Nohara, Tomohiro Imamura, Akihiro Yamaguchi, Maho Hidari, Kazuya I. P. J. Suzuki, Takashi Komori, Tatsuya Ando, Hiromune Ishida, Hideharu Kiso, Makoto Molecules Article A novel ganglioside bearing Neuα2-3Gal and Neuα2-6Gal structures as distal sequences was designed as a ligand for influenza A viruses. The efficient synthesis of the designed ganglioside was accomplished by employing the cassette coupling approach as a key reaction, which was executed between the non-reducing end of the oligosaccharide and the cyclic glucosylceramide moiety. Examination of its binding activity to influenza A viruses revealed that the new ligand is recognized by Neuα2-3 and 2-6 type viruses. MDPI 2012-08-10 /pmc/articles/PMC6269081/ /pubmed/22885358 http://dx.doi.org/10.3390/molecules17089590 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Nohara, Tomohiro Imamura, Akihiro Yamaguchi, Maho Hidari, Kazuya I. P. J. Suzuki, Takashi Komori, Tatsuya Ando, Hiromune Ishida, Hideharu Kiso, Makoto Design and Synthesis of a Novel Ganglioside Ligand for Influenza A Viruses (†) |
title | Design and Synthesis of a Novel Ganglioside Ligand for Influenza A Viruses (†) |
title_full | Design and Synthesis of a Novel Ganglioside Ligand for Influenza A Viruses (†) |
title_fullStr | Design and Synthesis of a Novel Ganglioside Ligand for Influenza A Viruses (†) |
title_full_unstemmed | Design and Synthesis of a Novel Ganglioside Ligand for Influenza A Viruses (†) |
title_short | Design and Synthesis of a Novel Ganglioside Ligand for Influenza A Viruses (†) |
title_sort | design and synthesis of a novel ganglioside ligand for influenza a viruses (†) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269081/ https://www.ncbi.nlm.nih.gov/pubmed/22885358 http://dx.doi.org/10.3390/molecules17089590 |
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