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Quercetin Improves Baroreflex Sensitivity in Spontaneously Hypertensive Rats

Quercetin is a well-known antioxidant. Here, we investigated the effects of treatment with quercetin on mean arterial pressure (MAP), heart rate (HR) and baroreflex sensitivity (BRS) in spontaneously hypertensive rats (SHR). SHR and their controls (WKY) were orally treated with quercetin (2, 10 or 2...

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Autores principales: Monteiro, Matheus M. O., França-Silva, Maria S., Alves, Naiane F. B., Porpino, Suênia K. P., Braga, Valdir A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269113/
https://www.ncbi.nlm.nih.gov/pubmed/23117438
http://dx.doi.org/10.3390/molecules171112997
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author Monteiro, Matheus M. O.
França-Silva, Maria S.
Alves, Naiane F. B.
Porpino, Suênia K. P.
Braga, Valdir A.
author_facet Monteiro, Matheus M. O.
França-Silva, Maria S.
Alves, Naiane F. B.
Porpino, Suênia K. P.
Braga, Valdir A.
author_sort Monteiro, Matheus M. O.
collection PubMed
description Quercetin is a well-known antioxidant. Here, we investigated the effects of treatment with quercetin on mean arterial pressure (MAP), heart rate (HR) and baroreflex sensitivity (BRS) in spontaneously hypertensive rats (SHR). SHR and their controls (WKY) were orally treated with quercetin (2, 10 or 25 mg/kg/day) or saline for seven days. On the 8th day, MAP and HR were recorded. BRS was tested using phenylephrine (8 mg/kg, i.v.) and sodium nitroprusside (25 mg/kg, i.v.). Oxidative stress was measured by tiobarbituric acid reactive species assay. The doses of 10 (n = 8) and 25 mg/kg (n = 8) were able to decrease the MAP in SHR (n = 9) (163 ± 4 and 156 ± 5 vs. 173 ± 6, respectively, p < 0.05) but not in WKY (117 ± 1 and 118 ± 2 vs. 113 ± 1, respectively, p < 0.05). The dose of 25 mg/kg/day increased the sensitivity of parasympathetic component of the baroreflex (−2.47 ± 0.31 vs. −1.25 ± 0.8 bpm/mmHg) and decreased serum oxidative stress in SHR (2.04 ± 0.17 vs. 3.22 ± 0.37 nmol/mL, n = 6). Our data suggest that treatment with quercetin reduces hypertension and improves BRS in SHR via reduction in oxidative stress.
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spelling pubmed-62691132018-12-13 Quercetin Improves Baroreflex Sensitivity in Spontaneously Hypertensive Rats Monteiro, Matheus M. O. França-Silva, Maria S. Alves, Naiane F. B. Porpino, Suênia K. P. Braga, Valdir A. Molecules Article Quercetin is a well-known antioxidant. Here, we investigated the effects of treatment with quercetin on mean arterial pressure (MAP), heart rate (HR) and baroreflex sensitivity (BRS) in spontaneously hypertensive rats (SHR). SHR and their controls (WKY) were orally treated with quercetin (2, 10 or 25 mg/kg/day) or saline for seven days. On the 8th day, MAP and HR were recorded. BRS was tested using phenylephrine (8 mg/kg, i.v.) and sodium nitroprusside (25 mg/kg, i.v.). Oxidative stress was measured by tiobarbituric acid reactive species assay. The doses of 10 (n = 8) and 25 mg/kg (n = 8) were able to decrease the MAP in SHR (n = 9) (163 ± 4 and 156 ± 5 vs. 173 ± 6, respectively, p < 0.05) but not in WKY (117 ± 1 and 118 ± 2 vs. 113 ± 1, respectively, p < 0.05). The dose of 25 mg/kg/day increased the sensitivity of parasympathetic component of the baroreflex (−2.47 ± 0.31 vs. −1.25 ± 0.8 bpm/mmHg) and decreased serum oxidative stress in SHR (2.04 ± 0.17 vs. 3.22 ± 0.37 nmol/mL, n = 6). Our data suggest that treatment with quercetin reduces hypertension and improves BRS in SHR via reduction in oxidative stress. MDPI 2012-11-01 /pmc/articles/PMC6269113/ /pubmed/23117438 http://dx.doi.org/10.3390/molecules171112997 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Monteiro, Matheus M. O.
França-Silva, Maria S.
Alves, Naiane F. B.
Porpino, Suênia K. P.
Braga, Valdir A.
Quercetin Improves Baroreflex Sensitivity in Spontaneously Hypertensive Rats
title Quercetin Improves Baroreflex Sensitivity in Spontaneously Hypertensive Rats
title_full Quercetin Improves Baroreflex Sensitivity in Spontaneously Hypertensive Rats
title_fullStr Quercetin Improves Baroreflex Sensitivity in Spontaneously Hypertensive Rats
title_full_unstemmed Quercetin Improves Baroreflex Sensitivity in Spontaneously Hypertensive Rats
title_short Quercetin Improves Baroreflex Sensitivity in Spontaneously Hypertensive Rats
title_sort quercetin improves baroreflex sensitivity in spontaneously hypertensive rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269113/
https://www.ncbi.nlm.nih.gov/pubmed/23117438
http://dx.doi.org/10.3390/molecules171112997
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