Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules

Helminths are extraordinarily successful parasites due to their ability to modulate the host immune response. They have evolved a spectrum of immunomodulatory molecules that are now beginning to be defined, heralding a molecular revolution in parasite immunology. These discoveries have the potential...

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Detalles Bibliográficos
Autores principales: Maizels, Rick M., Smits, Hermelijn H., McSorley, Henry J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269126/
https://www.ncbi.nlm.nih.gov/pubmed/30462997
http://dx.doi.org/10.1016/j.immuni.2018.10.016
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author Maizels, Rick M.
Smits, Hermelijn H.
McSorley, Henry J.
author_facet Maizels, Rick M.
Smits, Hermelijn H.
McSorley, Henry J.
author_sort Maizels, Rick M.
collection PubMed
description Helminths are extraordinarily successful parasites due to their ability to modulate the host immune response. They have evolved a spectrum of immunomodulatory molecules that are now beginning to be defined, heralding a molecular revolution in parasite immunology. These discoveries have the potential both to transform our understanding of parasite adaptation to the host and to develop possible therapies for immune-mediated disease. In this review we will summarize the current state of the art in parasite immunomodulation and discuss perspectives on future areas for research and discovery.
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spelling pubmed-62691262018-12-06 Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules Maizels, Rick M. Smits, Hermelijn H. McSorley, Henry J. Immunity Article Helminths are extraordinarily successful parasites due to their ability to modulate the host immune response. They have evolved a spectrum of immunomodulatory molecules that are now beginning to be defined, heralding a molecular revolution in parasite immunology. These discoveries have the potential both to transform our understanding of parasite adaptation to the host and to develop possible therapies for immune-mediated disease. In this review we will summarize the current state of the art in parasite immunomodulation and discuss perspectives on future areas for research and discovery. Cell Press 2018-11-20 /pmc/articles/PMC6269126/ /pubmed/30462997 http://dx.doi.org/10.1016/j.immuni.2018.10.016 Text en © 2018 The Authors. Published by Elsevier Inc. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Maizels, Rick M.
Smits, Hermelijn H.
McSorley, Henry J.
Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules
title Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules
title_full Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules
title_fullStr Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules
title_full_unstemmed Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules
title_short Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules
title_sort modulation of host immunity by helminths: the expanding repertoire of parasite effector molecules
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269126/
https://www.ncbi.nlm.nih.gov/pubmed/30462997
http://dx.doi.org/10.1016/j.immuni.2018.10.016
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