Cargando…
A Method to Measure the Rate of Glaucomatous Visual Field Change
PURPOSE: To develop a method to measure the rate of glaucomatous visual field (VF) deterioration and to identify fast progressors. METHODS: Retrospective, longitudinal, observational study of 8486 eyes of 4610 glaucomatous patients with ≥6 VFs and ≥3 years of follow-up. A Glaucoma Rate Index (GRI) w...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Association for Research in Vision and Ophthalmology
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269135/ https://www.ncbi.nlm.nih.gov/pubmed/30519499 http://dx.doi.org/10.1167/tvst.7.6.14 |
_version_ | 1783376441509937152 |
---|---|
author | Caprioli, Joseph Mohamed, Lilian Morales, Esteban Rabiolo, Alessandro Sears, Nathaniel Pradtana, Hirunpatravong Alizadeh, Reza Yu, Fei Afifi, Abdelmonem A. Coleman, Anne L. Nouri-Mahdavi, Kouros |
author_facet | Caprioli, Joseph Mohamed, Lilian Morales, Esteban Rabiolo, Alessandro Sears, Nathaniel Pradtana, Hirunpatravong Alizadeh, Reza Yu, Fei Afifi, Abdelmonem A. Coleman, Anne L. Nouri-Mahdavi, Kouros |
author_sort | Caprioli, Joseph |
collection | PubMed |
description | PURPOSE: To develop a method to measure the rate of glaucomatous visual field (VF) deterioration and to identify fast progressors. METHODS: Retrospective, longitudinal, observational study of 8486 eyes of 4610 glaucomatous patients with ≥6 VFs and ≥3 years of follow-up. A Glaucoma Rate Index (GRI) was calculated. VF locations were partitioned into exponential decay or exponential improvement models. A pointwise rate of change (PRC) was estimated with an exponential fit and expressed as the percent/year change of the age- and location-matched normal perimetric range, presented as a spatially conserved VF map. PRCs were summed and normalized with boundary rates set by simulated decaying and improving VF series on a scale of −100 to +100, respectively. RESULTS: A total of 89,704 VF examinations with 425,039 test location series was used. Median follow-up and number of VFs/eye were 9.7 years and 9 VFs, respectively. Initial and final mean deviations (±SD) were −4.2 (±5.2) and −5.7 (±6.4) dB. The proportions of test locations designated as decayed, improved, and unchanged were 13%, 4%, and 83%, respectively. Mean PRCs for decay, improvement, and no change were −3.7 (±4.7)%/y, 2.5 (±2.6)%/y, and −0.5 (±2.1)%/y, respectively. The number of eyes with negative and positive GRIs was 5802 (68%) and 2390 eyes (28%), respectively. The proportion of eyes defined as fast progressors was 6.8%. CONCLUSIONS: GRI provides a robust measure of glaucomatous VF change, operates without discontinuity over the entire perimetric range, and can be used to identify fast progressors. TRANSLATIONAL RELEVANCE: This study describes a novel method that can help the clinician to determine VF progression. |
format | Online Article Text |
id | pubmed-6269135 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | The Association for Research in Vision and Ophthalmology |
record_format | MEDLINE/PubMed |
spelling | pubmed-62691352018-12-05 A Method to Measure the Rate of Glaucomatous Visual Field Change Caprioli, Joseph Mohamed, Lilian Morales, Esteban Rabiolo, Alessandro Sears, Nathaniel Pradtana, Hirunpatravong Alizadeh, Reza Yu, Fei Afifi, Abdelmonem A. Coleman, Anne L. Nouri-Mahdavi, Kouros Transl Vis Sci Technol Articles PURPOSE: To develop a method to measure the rate of glaucomatous visual field (VF) deterioration and to identify fast progressors. METHODS: Retrospective, longitudinal, observational study of 8486 eyes of 4610 glaucomatous patients with ≥6 VFs and ≥3 years of follow-up. A Glaucoma Rate Index (GRI) was calculated. VF locations were partitioned into exponential decay or exponential improvement models. A pointwise rate of change (PRC) was estimated with an exponential fit and expressed as the percent/year change of the age- and location-matched normal perimetric range, presented as a spatially conserved VF map. PRCs were summed and normalized with boundary rates set by simulated decaying and improving VF series on a scale of −100 to +100, respectively. RESULTS: A total of 89,704 VF examinations with 425,039 test location series was used. Median follow-up and number of VFs/eye were 9.7 years and 9 VFs, respectively. Initial and final mean deviations (±SD) were −4.2 (±5.2) and −5.7 (±6.4) dB. The proportions of test locations designated as decayed, improved, and unchanged were 13%, 4%, and 83%, respectively. Mean PRCs for decay, improvement, and no change were −3.7 (±4.7)%/y, 2.5 (±2.6)%/y, and −0.5 (±2.1)%/y, respectively. The number of eyes with negative and positive GRIs was 5802 (68%) and 2390 eyes (28%), respectively. The proportion of eyes defined as fast progressors was 6.8%. CONCLUSIONS: GRI provides a robust measure of glaucomatous VF change, operates without discontinuity over the entire perimetric range, and can be used to identify fast progressors. TRANSLATIONAL RELEVANCE: This study describes a novel method that can help the clinician to determine VF progression. The Association for Research in Vision and Ophthalmology 2018-11-30 /pmc/articles/PMC6269135/ /pubmed/30519499 http://dx.doi.org/10.1167/tvst.7.6.14 Text en Copyright 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. |
spellingShingle | Articles Caprioli, Joseph Mohamed, Lilian Morales, Esteban Rabiolo, Alessandro Sears, Nathaniel Pradtana, Hirunpatravong Alizadeh, Reza Yu, Fei Afifi, Abdelmonem A. Coleman, Anne L. Nouri-Mahdavi, Kouros A Method to Measure the Rate of Glaucomatous Visual Field Change |
title | A Method to Measure the Rate of Glaucomatous Visual Field Change |
title_full | A Method to Measure the Rate of Glaucomatous Visual Field Change |
title_fullStr | A Method to Measure the Rate of Glaucomatous Visual Field Change |
title_full_unstemmed | A Method to Measure the Rate of Glaucomatous Visual Field Change |
title_short | A Method to Measure the Rate of Glaucomatous Visual Field Change |
title_sort | method to measure the rate of glaucomatous visual field change |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269135/ https://www.ncbi.nlm.nih.gov/pubmed/30519499 http://dx.doi.org/10.1167/tvst.7.6.14 |
work_keys_str_mv | AT capriolijoseph amethodtomeasuretherateofglaucomatousvisualfieldchange AT mohamedlilian amethodtomeasuretherateofglaucomatousvisualfieldchange AT moralesesteban amethodtomeasuretherateofglaucomatousvisualfieldchange AT rabioloalessandro amethodtomeasuretherateofglaucomatousvisualfieldchange AT searsnathaniel amethodtomeasuretherateofglaucomatousvisualfieldchange AT pradtanahirunpatravong amethodtomeasuretherateofglaucomatousvisualfieldchange AT alizadehreza amethodtomeasuretherateofglaucomatousvisualfieldchange AT yufei amethodtomeasuretherateofglaucomatousvisualfieldchange AT afifiabdelmonema amethodtomeasuretherateofglaucomatousvisualfieldchange AT colemanannel amethodtomeasuretherateofglaucomatousvisualfieldchange AT nourimahdavikouros amethodtomeasuretherateofglaucomatousvisualfieldchange AT capriolijoseph methodtomeasuretherateofglaucomatousvisualfieldchange AT mohamedlilian methodtomeasuretherateofglaucomatousvisualfieldchange AT moralesesteban methodtomeasuretherateofglaucomatousvisualfieldchange AT rabioloalessandro methodtomeasuretherateofglaucomatousvisualfieldchange AT searsnathaniel methodtomeasuretherateofglaucomatousvisualfieldchange AT pradtanahirunpatravong methodtomeasuretherateofglaucomatousvisualfieldchange AT alizadehreza methodtomeasuretherateofglaucomatousvisualfieldchange AT yufei methodtomeasuretherateofglaucomatousvisualfieldchange AT afifiabdelmonema methodtomeasuretherateofglaucomatousvisualfieldchange AT colemanannel methodtomeasuretherateofglaucomatousvisualfieldchange AT nourimahdavikouros methodtomeasuretherateofglaucomatousvisualfieldchange |