A luciferase complementation assay system using transferable mouse artificial chromosomes to monitor protein–protein interactions mediated by G protein-coupled receptors

G protein-coupled receptors (GPCRs) are seven-transmembrane domain receptors that interact with the β-arrestin family, particularly β-arrestin 1 (ARRB1). GPCRs interact with 33% of small molecule drugs. Ligand screening is promising for drug discovery concerning GPCR-related diseases. Luciferase com...

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Detalles Bibliográficos
Autores principales: Uno, Narumi, Fujimoto, Tomohito, Komoto, Shinya, Kurosawa, Gene, Sawa, Masaaki, Suzuki, Teruhiko, Kazuki, Yasuhiro, Oshimura, Mitsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269364/
https://www.ncbi.nlm.nih.gov/pubmed/30112660
http://dx.doi.org/10.1007/s10616-018-0231-7

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