Usp16 modulates Wnt signaling in primary tissues through Cdkn2a regulation

Regulation of the Wnt pathway in stem cells and primary tissues is still poorly understood. Here we report that Usp16, a negative regulator of Bmi1/PRC1 function, modulates the Wnt pathway in mammary epithelia, primary human fibroblasts and MEFs, affecting their expansion and self-renewal potential....

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Detalles Bibliográficos
Autores principales: Adorno, Maddalena, di Robilant, Benedetta Nicolis, Sikandar, Shaheen Shabbir, Acosta, Veronica Haro, Antony, Jane, Heller, Craig H., Clarke, Michael F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269430/
https://www.ncbi.nlm.nih.gov/pubmed/30504774
http://dx.doi.org/10.1038/s41598-018-34562-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269430/
https://www.ncbi.nlm.nih.gov/pubmed/30504774
http://dx.doi.org/10.1038/s41598-018-34562-w

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