Striatal dopamine deficits predict reductions in striatal functional connectivity in major depression: a concurrent (11)C-raclopride positron emission tomography and functional magnetic resonance imaging investigation

Major depressive disorder (MDD) is characterized by the altered integration of reward histories and reduced responding of the striatum. We have posited that this reduced striatal activation in MDD is due to tonically decreased stimulation of striatal dopamine synapses which results in decremented pr...

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Detalles Bibliográficos
Autores principales: Hamilton, J. Paul, Sacchet, Matthew D., Hjørnevik, Trine, Chin, Frederick T., Shen, Bin, Kämpe, Robin, Park, Jun Hyung, Knutson, Brian D., Williams, Leanne M., Borg, Nicholas, Zaharchuk, Greg, Camacho, M. Catalina, Mackey, Sean, Heilig, Markus, Drevets, Wayne C., Glover, Gary H., Gambhir, Sanjiv S., Gotlib, Ian H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269434/
https://www.ncbi.nlm.nih.gov/pubmed/30504860
http://dx.doi.org/10.1038/s41398-018-0316-2

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