Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression

Neutrophils are a vital component of immune protection, yet in cancer they may promote tumour progression, partly by generating reactive oxygen species (ROS) that disrupts lymphocyte functions. Metabolically, neutrophils are often discounted as purely glycolytic. Here we show that immature, c-Kit(+)...

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Detalles Bibliográficos
Autores principales: Rice, Christopher M., Davies, Luke C., Subleski, Jeff J., Maio, Nunziata, Gonzalez-Cotto, Marieli, Andrews, Caroline, Patel, Nimit L., Palmieri, Erika M., Weiss, Jonathan M., Lee, Jung-Min, Annunziata, Christina M., Rouault, Tracey A., Durum, Scott K., McVicar, Daniel W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269473/
https://www.ncbi.nlm.nih.gov/pubmed/30504842
http://dx.doi.org/10.1038/s41467-018-07505-2

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