Cytoplasmic LIF reprograms invasive mode to enhance NPC dissemination through modulating YAP1-FAK/PXN signaling

Metastasis remains a clinically unsolved issue in nasopharyngeal carcinoma. Here, we report that higher levels of cytoplasmic leukemia inhibitory factor (LIF) and LIF receptor are correlated with poorer metastasis/recurrence-free survival. Further, single nucleotide variations and signal peptide mut...

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Detalles Bibliográficos
Autores principales: Liu, Shu-Chen, Hsu, Tien, Chang, Yu-Sun, Chung, An-Ko, Jiang, Shih Sheng, OuYang, Chun-Nan, Yuh, Chiou-Hwa, Hsueh, Chuen, Liu, Ya-Ping, Tsang, Ngan-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269507/
https://www.ncbi.nlm.nih.gov/pubmed/30504771
http://dx.doi.org/10.1038/s41467-018-07660-6

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