ROBO2 is a stroma suppressor gene in the pancreas and acts via TGF-β signalling

Whereas genomic aberrations in the SLIT-ROBO pathway are frequent in pancreatic ductal adenocarcinoma (PDAC), their function in the pancreas is unclear. Here we report that in pancreatitis and PDAC mouse models, epithelial Robo2 expression is lost while Robo1 expression becomes most prominent in the...

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Detalles Bibliográficos
Autores principales: Pinho, Andreia V., Van Bulck, Mathias, Chantrill, Lorraine, Arshi, Mehreen, Sklyarova, Tatyana, Herrmann, David, Vennin, Claire, Gallego-Ortega, David, Mawson, Amanda, Giry-Laterriere, Marc, Magenau, Astrid, Leuckx, Gunther, Baeyens, Luc, Gill, Anthony J., Phillips, Phoebe, Timpson, Paul, Biankin, Andrew V., Wu, Jianmin, Rooman, Ilse
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269509/
https://www.ncbi.nlm.nih.gov/pubmed/30504844
http://dx.doi.org/10.1038/s41467-018-07497-z

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