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Real-time assembly of ribonucleoprotein complexes on nascent RNA transcripts
Cellular protein-RNA complexes assemble on nascent transcripts, but methods to observe transcription and protein binding in real time and at physiological concentrations are not available. Here, we report a single-molecule approach based on zero-mode waveguides that simultaneously tracks transcripti...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269517/ https://www.ncbi.nlm.nih.gov/pubmed/30504830 http://dx.doi.org/10.1038/s41467-018-07423-3 |