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The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa
There is paucity of data regarding the geographical distribution, incidence, and phylogenetics of multi-drug resistant (MDR) Salmonella Typhi in sub-Saharan Africa. Here we present a phylogenetic reconstruction of whole genome sequenced 249 contemporaneous S. Typhi isolated between 2008-2015 in 11 s...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269545/ https://www.ncbi.nlm.nih.gov/pubmed/30504848 http://dx.doi.org/10.1038/s41467-018-07370-z |
| _version_ | 1783376494275330048 |
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| author | Park, Se Eun Pham, Duy Thanh Boinett, Christine Wong, Vanessa K. Pak, Gi Deok Panzner, Ursula Espinoza, Ligia Maria Cruz von Kalckreuth, Vera Im, Justin Schütt-Gerowitt, Heidi Crump, John A. Breiman, Robert F. Adu-Sarkodie, Yaw Owusu-Dabo, Ellis Rakotozandrindrainy, Raphaël Soura, Abdramane Bassiahi Aseffa, Abraham Gasmelseed, Nagla Keddy, Karen H. May, Jürgen Sow, Amy Gassama Aaby, Peter Biggs, Holly M. Hertz, Julian T. Montgomery, Joel M. Cosmas, Leonard Olack, Beatrice Fields, Barry Sarpong, Nimako Razafindrabe, Tsiriniaina Jean Luco Raminosoa, Tiana Mirana Kabore, Leon Parfait Sampo, Emmanuel Teferi, Mekonnen Yeshitela, Biruk El Tayeb, Muna Ahmed Sooka, Arvinda Meyer, Christian G. Krumkamp, Ralf Dekker, Denise Myriam Jaeger, Anna Poppert, Sven Tall, Adama Niang, Aissatou Bjerregaard-Andersen, Morten Løfberg, Sandra Valborg Seo, Hye Jin Jeon, Hyon Jin Deerin, Jessica Fung Park, Jinkyung Konings, Frank Ali, Mohammad Clemens, John D. Hughes, Peter Sendagala, Juliet Nsimire Vudriko, Tobias Downing, Robert Ikumapayi, Usman N. Mackenzie, Grant A. Obaro, Stephen Argimon, Silvia Aanensen, David M. Page, Andrew Keane, Jacqueline A. Duchene, Sebastian Dyson, Zoe Holt, Kathryn E. Dougan, Gordon Marks, Florian Baker, Stephen |
| author_facet | Park, Se Eun Pham, Duy Thanh Boinett, Christine Wong, Vanessa K. Pak, Gi Deok Panzner, Ursula Espinoza, Ligia Maria Cruz von Kalckreuth, Vera Im, Justin Schütt-Gerowitt, Heidi Crump, John A. Breiman, Robert F. Adu-Sarkodie, Yaw Owusu-Dabo, Ellis Rakotozandrindrainy, Raphaël Soura, Abdramane Bassiahi Aseffa, Abraham Gasmelseed, Nagla Keddy, Karen H. May, Jürgen Sow, Amy Gassama Aaby, Peter Biggs, Holly M. Hertz, Julian T. Montgomery, Joel M. Cosmas, Leonard Olack, Beatrice Fields, Barry Sarpong, Nimako Razafindrabe, Tsiriniaina Jean Luco Raminosoa, Tiana Mirana Kabore, Leon Parfait Sampo, Emmanuel Teferi, Mekonnen Yeshitela, Biruk El Tayeb, Muna Ahmed Sooka, Arvinda Meyer, Christian G. Krumkamp, Ralf Dekker, Denise Myriam Jaeger, Anna Poppert, Sven Tall, Adama Niang, Aissatou Bjerregaard-Andersen, Morten Løfberg, Sandra Valborg Seo, Hye Jin Jeon, Hyon Jin Deerin, Jessica Fung Park, Jinkyung Konings, Frank Ali, Mohammad Clemens, John D. Hughes, Peter Sendagala, Juliet Nsimire Vudriko, Tobias Downing, Robert Ikumapayi, Usman N. Mackenzie, Grant A. Obaro, Stephen Argimon, Silvia Aanensen, David M. Page, Andrew Keane, Jacqueline A. Duchene, Sebastian Dyson, Zoe Holt, Kathryn E. Dougan, Gordon Marks, Florian Baker, Stephen |
| author_sort | Park, Se Eun |
| collection | PubMed |
| description | There is paucity of data regarding the geographical distribution, incidence, and phylogenetics of multi-drug resistant (MDR) Salmonella Typhi in sub-Saharan Africa. Here we present a phylogenetic reconstruction of whole genome sequenced 249 contemporaneous S. Typhi isolated between 2008-2015 in 11 sub-Saharan African countries, in context of the 2,057 global S. Typhi genomic framework. Despite the broad genetic diversity, the majority of organisms (225/249; 90%) belong to only three genotypes, 4.3.1 (H58) (99/249; 40%), 3.1.1 (97/249; 39%), and 2.3.2 (29/249; 12%). Genotypes 4.3.1 and 3.1.1 are confined within East and West Africa, respectively. MDR phenotype is found in over 50% of organisms restricted within these dominant genotypes. High incidences of MDR S. Typhi are calculated in locations with a high burden of typhoid, specifically in children aged <15 years. Antimicrobial stewardship, MDR surveillance, and the introduction of typhoid conjugate vaccines will be critical for the control of MDR typhoid in Africa. |
| format | Online Article Text |
| id | pubmed-6269545 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-62695452018-12-03 The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa Park, Se Eun Pham, Duy Thanh Boinett, Christine Wong, Vanessa K. Pak, Gi Deok Panzner, Ursula Espinoza, Ligia Maria Cruz von Kalckreuth, Vera Im, Justin Schütt-Gerowitt, Heidi Crump, John A. Breiman, Robert F. Adu-Sarkodie, Yaw Owusu-Dabo, Ellis Rakotozandrindrainy, Raphaël Soura, Abdramane Bassiahi Aseffa, Abraham Gasmelseed, Nagla Keddy, Karen H. May, Jürgen Sow, Amy Gassama Aaby, Peter Biggs, Holly M. Hertz, Julian T. Montgomery, Joel M. Cosmas, Leonard Olack, Beatrice Fields, Barry Sarpong, Nimako Razafindrabe, Tsiriniaina Jean Luco Raminosoa, Tiana Mirana Kabore, Leon Parfait Sampo, Emmanuel Teferi, Mekonnen Yeshitela, Biruk El Tayeb, Muna Ahmed Sooka, Arvinda Meyer, Christian G. Krumkamp, Ralf Dekker, Denise Myriam Jaeger, Anna Poppert, Sven Tall, Adama Niang, Aissatou Bjerregaard-Andersen, Morten Løfberg, Sandra Valborg Seo, Hye Jin Jeon, Hyon Jin Deerin, Jessica Fung Park, Jinkyung Konings, Frank Ali, Mohammad Clemens, John D. Hughes, Peter Sendagala, Juliet Nsimire Vudriko, Tobias Downing, Robert Ikumapayi, Usman N. Mackenzie, Grant A. Obaro, Stephen Argimon, Silvia Aanensen, David M. Page, Andrew Keane, Jacqueline A. Duchene, Sebastian Dyson, Zoe Holt, Kathryn E. Dougan, Gordon Marks, Florian Baker, Stephen Nat Commun Article There is paucity of data regarding the geographical distribution, incidence, and phylogenetics of multi-drug resistant (MDR) Salmonella Typhi in sub-Saharan Africa. Here we present a phylogenetic reconstruction of whole genome sequenced 249 contemporaneous S. Typhi isolated between 2008-2015 in 11 sub-Saharan African countries, in context of the 2,057 global S. Typhi genomic framework. Despite the broad genetic diversity, the majority of organisms (225/249; 90%) belong to only three genotypes, 4.3.1 (H58) (99/249; 40%), 3.1.1 (97/249; 39%), and 2.3.2 (29/249; 12%). Genotypes 4.3.1 and 3.1.1 are confined within East and West Africa, respectively. MDR phenotype is found in over 50% of organisms restricted within these dominant genotypes. High incidences of MDR S. Typhi are calculated in locations with a high burden of typhoid, specifically in children aged <15 years. Antimicrobial stewardship, MDR surveillance, and the introduction of typhoid conjugate vaccines will be critical for the control of MDR typhoid in Africa. Nature Publishing Group UK 2018-11-30 /pmc/articles/PMC6269545/ /pubmed/30504848 http://dx.doi.org/10.1038/s41467-018-07370-z Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Article Park, Se Eun Pham, Duy Thanh Boinett, Christine Wong, Vanessa K. Pak, Gi Deok Panzner, Ursula Espinoza, Ligia Maria Cruz von Kalckreuth, Vera Im, Justin Schütt-Gerowitt, Heidi Crump, John A. Breiman, Robert F. Adu-Sarkodie, Yaw Owusu-Dabo, Ellis Rakotozandrindrainy, Raphaël Soura, Abdramane Bassiahi Aseffa, Abraham Gasmelseed, Nagla Keddy, Karen H. May, Jürgen Sow, Amy Gassama Aaby, Peter Biggs, Holly M. Hertz, Julian T. Montgomery, Joel M. Cosmas, Leonard Olack, Beatrice Fields, Barry Sarpong, Nimako Razafindrabe, Tsiriniaina Jean Luco Raminosoa, Tiana Mirana Kabore, Leon Parfait Sampo, Emmanuel Teferi, Mekonnen Yeshitela, Biruk El Tayeb, Muna Ahmed Sooka, Arvinda Meyer, Christian G. Krumkamp, Ralf Dekker, Denise Myriam Jaeger, Anna Poppert, Sven Tall, Adama Niang, Aissatou Bjerregaard-Andersen, Morten Løfberg, Sandra Valborg Seo, Hye Jin Jeon, Hyon Jin Deerin, Jessica Fung Park, Jinkyung Konings, Frank Ali, Mohammad Clemens, John D. Hughes, Peter Sendagala, Juliet Nsimire Vudriko, Tobias Downing, Robert Ikumapayi, Usman N. Mackenzie, Grant A. Obaro, Stephen Argimon, Silvia Aanensen, David M. Page, Andrew Keane, Jacqueline A. Duchene, Sebastian Dyson, Zoe Holt, Kathryn E. Dougan, Gordon Marks, Florian Baker, Stephen The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa |
| title | The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa |
| title_full | The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa |
| title_fullStr | The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa |
| title_full_unstemmed | The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa |
| title_short | The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa |
| title_sort | phylogeography and incidence of multi-drug resistant typhoid fever in sub-saharan africa |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269545/ https://www.ncbi.nlm.nih.gov/pubmed/30504848 http://dx.doi.org/10.1038/s41467-018-07370-z |
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