Design, Synthesis and Biological Evaluation of New Imidazo[2,1-b]Thiazole Derivatives as Selective COX-2 Inhibitors

A new series of imidazo[2,1-b]thiazole analogs containing a methyl sulfonyl COX-2 pharmacophore was synthesized and evaluated for their COX-2 inhibitory activity. According to in-vitro COX-1/COX-2 inhibition data, all compounds (6a-g) were selective inhibitors of COX-2 isoenzyme with IC(50) values i...

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Detalles Bibliográficos
Autores principales: Shahrasbi, Mahsa, Azami Movahed, Mahsa, Ghorban Dadras, Orkideh, Daraei, Bahram, Zarghi, Afshin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2018
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Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269562/
https://www.ncbi.nlm.nih.gov/pubmed/30568687

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