Influence of DOTA Chelators on Radiochemical Purity and Biodistribution of (177)Lu- and (90)Y-Rituximab in Xenografted Mice

This work presents a comparative biological evaluation of (90)Y- and (177)Lu- labelled DOTA-SCN and DOTA-NHS conjugated to Rituximab in tumour-bearing mice. Two DOTA derivatives, p-SCN-Bn-DOTA and DOTA-NHS-ester were conjugated to Rituximab and then freeze-dried kit formulations were prepared, as pr...

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Detalles Bibliográficos
Autores principales: Karczmarczyk, Urszula, Wojdowska, Wioletta, Mikołajczak, Renata, Maurin, Michał, Laszuk, Ewa, Garnuszek, Piotr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269569/
https://www.ncbi.nlm.nih.gov/pubmed/30568680

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