Subtotal Splenectomy in Hereditary Spherocytosis - Advantages and Disadvantages

ABSTRACT: Hereditary spherocytosis (HS) represents the most frequent hemolytic anemia in Central and Northern Europe consisting in an inherited abnormality of the red blood cell (RBC) membrane. It is usually transmitted as an autosomal dominant disorder; 25% of cases are without family history. Sple...

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Autores principales: BICĂ, C., CISMARU, L., STĂNESCU, L., BICĂ, M, MARINESCU, D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medical University Publishing House Craiova 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269614/
https://www.ncbi.nlm.nih.gov/pubmed/30581596
http://dx.doi.org/10.12865/CHSJ.42.04.11
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author BICĂ, C.
CISMARU, L.
STĂNESCU, L.
BICĂ, M
MARINESCU, D.
author_facet BICĂ, C.
CISMARU, L.
STĂNESCU, L.
BICĂ, M
MARINESCU, D.
author_sort BICĂ, C.
collection PubMed
description ABSTRACT: Hereditary spherocytosis (HS) represents the most frequent hemolytic anemia in Central and Northern Europe consisting in an inherited abnormality of the red blood cell (RBC) membrane. It is usually transmitted as an autosomal dominant disorder; 25% of cases are without family history. Splenectomy is the classical conception and it can cure hemolysis, being the treatment of choice for moderate to severe forms of HS. A new approach is accepted nowadays, subtotal splenectomy, thus eliminating the lifelong risk of postsplenectomy infections. We present two cases of HS treated by subtotal splenectomy, alongside the advantages and disadvantages of this therapy.
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spelling pubmed-62696142018-12-21 Subtotal Splenectomy in Hereditary Spherocytosis - Advantages and Disadvantages BICĂ, C. CISMARU, L. STĂNESCU, L. BICĂ, M MARINESCU, D. Curr Health Sci J Case Report ABSTRACT: Hereditary spherocytosis (HS) represents the most frequent hemolytic anemia in Central and Northern Europe consisting in an inherited abnormality of the red blood cell (RBC) membrane. It is usually transmitted as an autosomal dominant disorder; 25% of cases are without family history. Splenectomy is the classical conception and it can cure hemolysis, being the treatment of choice for moderate to severe forms of HS. A new approach is accepted nowadays, subtotal splenectomy, thus eliminating the lifelong risk of postsplenectomy infections. We present two cases of HS treated by subtotal splenectomy, alongside the advantages and disadvantages of this therapy. Medical University Publishing House Craiova 2016 2016-02-28 /pmc/articles/PMC6269614/ /pubmed/30581596 http://dx.doi.org/10.12865/CHSJ.42.04.11 Text en Copyright © 2016, Medical University Publishing House Craiova http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited.
spellingShingle Case Report
BICĂ, C.
CISMARU, L.
STĂNESCU, L.
BICĂ, M
MARINESCU, D.
Subtotal Splenectomy in Hereditary Spherocytosis - Advantages and Disadvantages
title Subtotal Splenectomy in Hereditary Spherocytosis - Advantages and Disadvantages
title_full Subtotal Splenectomy in Hereditary Spherocytosis - Advantages and Disadvantages
title_fullStr Subtotal Splenectomy in Hereditary Spherocytosis - Advantages and Disadvantages
title_full_unstemmed Subtotal Splenectomy in Hereditary Spherocytosis - Advantages and Disadvantages
title_short Subtotal Splenectomy in Hereditary Spherocytosis - Advantages and Disadvantages
title_sort subtotal splenectomy in hereditary spherocytosis - advantages and disadvantages
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269614/
https://www.ncbi.nlm.nih.gov/pubmed/30581596
http://dx.doi.org/10.12865/CHSJ.42.04.11
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