Assessment of Oxidative Stress Genes SOD2 and SOD3 Polymorphisms Role in Human Colorectal Cancer

Purpose: The aim of this study was to ascertain the oxidative stress genes SOD2 and SOD3 polymorphisms in patients with colorectal cancer and to assess the possible involvement of these polymorphisms that might increase the risk for patients to develop malignant intestinal tumors. Material and metho...

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Autores principales: MARGINEAN, C., STREATA, I., IOANA, M., MARGINEAN, O.M., PADUREANU, V., SAFTOIU, A., PETRESCU, I., TUDORACHE, S., TICA, O.S., PETRESCU, F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medical University Publishing House Craiova 2016
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269622/
https://www.ncbi.nlm.nih.gov/pubmed/30581589
http://dx.doi.org/10.12865/CHSJ.42.04.04
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author MARGINEAN, C.
STREATA, I.
IOANA, M.
MARGINEAN, O.M.
PADUREANU, V.
SAFTOIU, A.
PETRESCU, I.
TUDORACHE, S.
TICA, O.S.
PETRESCU, F.
author_facet MARGINEAN, C.
STREATA, I.
IOANA, M.
MARGINEAN, O.M.
PADUREANU, V.
SAFTOIU, A.
PETRESCU, I.
TUDORACHE, S.
TICA, O.S.
PETRESCU, F.
author_sort MARGINEAN, C.
collection PubMed
description Purpose: The aim of this study was to ascertain the oxidative stress genes SOD2 and SOD3 polymorphisms in patients with colorectal cancer and to assess the possible involvement of these polymorphisms that might increase the risk for patients to develop malignant intestinal tumors. Material and methods: A total number of 306 subjects were divided into two groups (109 colorectal cancer patients as the study group and 197 normal healthy individuals as the control group).We genotyped two polymorphisms, SOD2 – 201A>G (rs4880) and SOD3 – 896C>G (rs1799895), by allelic discrimination, with TaqMan RT-PCR specific probes. Results: No significant differences were found with either of the polymorphisms when comparing the association between them and an increased risk of developing colorectal tumors. Conclusion: In Romanian population, the risk of developing colorectal cancer is not increased by SOD2 and SOD3 polymorphisms.
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spelling pubmed-62696222018-12-21 Assessment of Oxidative Stress Genes SOD2 and SOD3 Polymorphisms Role in Human Colorectal Cancer MARGINEAN, C. STREATA, I. IOANA, M. MARGINEAN, O.M. PADUREANU, V. SAFTOIU, A. PETRESCU, I. TUDORACHE, S. TICA, O.S. PETRESCU, F. Curr Health Sci J Original Paper Purpose: The aim of this study was to ascertain the oxidative stress genes SOD2 and SOD3 polymorphisms in patients with colorectal cancer and to assess the possible involvement of these polymorphisms that might increase the risk for patients to develop malignant intestinal tumors. Material and methods: A total number of 306 subjects were divided into two groups (109 colorectal cancer patients as the study group and 197 normal healthy individuals as the control group).We genotyped two polymorphisms, SOD2 – 201A>G (rs4880) and SOD3 – 896C>G (rs1799895), by allelic discrimination, with TaqMan RT-PCR specific probes. Results: No significant differences were found with either of the polymorphisms when comparing the association between them and an increased risk of developing colorectal tumors. Conclusion: In Romanian population, the risk of developing colorectal cancer is not increased by SOD2 and SOD3 polymorphisms. Medical University Publishing House Craiova 2016 2016-02-28 /pmc/articles/PMC6269622/ /pubmed/30581589 http://dx.doi.org/10.12865/CHSJ.42.04.04 Text en Copyright © 2016, Medical University Publishing House Craiova http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited.
spellingShingle Original Paper
MARGINEAN, C.
STREATA, I.
IOANA, M.
MARGINEAN, O.M.
PADUREANU, V.
SAFTOIU, A.
PETRESCU, I.
TUDORACHE, S.
TICA, O.S.
PETRESCU, F.
Assessment of Oxidative Stress Genes SOD2 and SOD3 Polymorphisms Role in Human Colorectal Cancer
title Assessment of Oxidative Stress Genes SOD2 and SOD3 Polymorphisms Role in Human Colorectal Cancer
title_full Assessment of Oxidative Stress Genes SOD2 and SOD3 Polymorphisms Role in Human Colorectal Cancer
title_fullStr Assessment of Oxidative Stress Genes SOD2 and SOD3 Polymorphisms Role in Human Colorectal Cancer
title_full_unstemmed Assessment of Oxidative Stress Genes SOD2 and SOD3 Polymorphisms Role in Human Colorectal Cancer
title_short Assessment of Oxidative Stress Genes SOD2 and SOD3 Polymorphisms Role in Human Colorectal Cancer
title_sort assessment of oxidative stress genes sod2 and sod3 polymorphisms role in human colorectal cancer
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269622/
https://www.ncbi.nlm.nih.gov/pubmed/30581589
http://dx.doi.org/10.12865/CHSJ.42.04.04
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