Anti-Inflammatory Cycloartane-Type Saponins of Astragalus membranaceus

A new cycloartane-type triterpene glycoside, agroastragaloside V (1) was isolated from the roots of Astragalus membranaceus. The structure was identified as 3-O-β-(2'-O-acetyl)-d-xylopyranosyl-6-O-β-d-glucopyranosyl-(24S)-3β,6α,24α,25-tetrahydroxy-9,19-cyclolanostane, by means of spectroscopic...

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Detalles Bibliográficos
Autores principales: Lee, Dae-Young, Noh, Hyung-Jun, Choi, Jehun, Lee, Kyeong-Hee, Lee, Min-Ho, Lee, Ji-Hyun, Hong, Yoonpyo, Lee, Seung-Eun, Kim, Seung-Yu, Kim, Geum-Soog
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269660/
https://www.ncbi.nlm.nih.gov/pubmed/23529032
http://dx.doi.org/10.3390/molecules18043725
Descripción
Sumario:A new cycloartane-type triterpene glycoside, agroastragaloside V (1) was isolated from the roots of Astragalus membranaceus. The structure was identified as 3-O-β-(2'-O-acetyl)-d-xylopyranosyl-6-O-β-d-glucopyranosyl-(24S)-3β,6α,24α,25-tetrahydroxy-9,19-cyclolanostane, by means of spectroscopic methods, including HR-FAB/MS, 1D NMR ((1)H, (13)C, DEPT), 2D NMR (gCOSY, gHSQC, gHMBC, NOESY), and IR spectroscopy. Four known cycloartane glycosides, namely, agroastragaloside I (2), agroastragaloside II (3), isoastragaloside II (4) and astragaloside IV (5) were also isolated. All isolated compounds were tested for the ability to inhibit LPS-induced nitric oxide production in RAW264.7 macrophages.

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