Sesquiterpenoids from the Herb of Leonurus japonicus

Two new sesquiterpenoids, (−)-(1S*,2S*,3R*)-3-ethoxycupar-5-ene-1,2-diol (1) and (−)-(1S*,4S*,9S*)-1,9-epoxybisabola-2,10-diene-4-ol (2), along with six known compounds 3−8, were isolated from the EtOH extract of the herb of Leonurus japonicus. Their structures were elucidated by physical and spectr...

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Detalles Bibliográficos
Autores principales: Xiong, Liang, Zhou, Qin-Mei, Peng, Cheng, Xie, Xiao-Fang, Guo, Li, Li, Xiao-Hong, Liu, Juan, Liu, Zhao-Hua, Dai, Ou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269672/
https://www.ncbi.nlm.nih.gov/pubmed/23629758
http://dx.doi.org/10.3390/molecules18055051
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author Xiong, Liang
Zhou, Qin-Mei
Peng, Cheng
Xie, Xiao-Fang
Guo, Li
Li, Xiao-Hong
Liu, Juan
Liu, Zhao-Hua
Dai, Ou
author_facet Xiong, Liang
Zhou, Qin-Mei
Peng, Cheng
Xie, Xiao-Fang
Guo, Li
Li, Xiao-Hong
Liu, Juan
Liu, Zhao-Hua
Dai, Ou
author_sort Xiong, Liang
collection PubMed
description Two new sesquiterpenoids, (−)-(1S*,2S*,3R*)-3-ethoxycupar-5-ene-1,2-diol (1) and (−)-(1S*,4S*,9S*)-1,9-epoxybisabola-2,10-diene-4-ol (2), along with six known compounds 3−8, were isolated from the EtOH extract of the herb of Leonurus japonicus. Their structures were elucidated by physical and spectroscopic analysis. In the in vitro assays, compounds 7 and 8 showed obvious antibacterial activity against several bacteria strains, while compound 3 significantly inhibited abnormal increase of platelet aggregation induced by ADP.
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spelling pubmed-62696722018-12-14 Sesquiterpenoids from the Herb of Leonurus japonicus Xiong, Liang Zhou, Qin-Mei Peng, Cheng Xie, Xiao-Fang Guo, Li Li, Xiao-Hong Liu, Juan Liu, Zhao-Hua Dai, Ou Molecules Article Two new sesquiterpenoids, (−)-(1S*,2S*,3R*)-3-ethoxycupar-5-ene-1,2-diol (1) and (−)-(1S*,4S*,9S*)-1,9-epoxybisabola-2,10-diene-4-ol (2), along with six known compounds 3−8, were isolated from the EtOH extract of the herb of Leonurus japonicus. Their structures were elucidated by physical and spectroscopic analysis. In the in vitro assays, compounds 7 and 8 showed obvious antibacterial activity against several bacteria strains, while compound 3 significantly inhibited abnormal increase of platelet aggregation induced by ADP. MDPI 2013-04-29 /pmc/articles/PMC6269672/ /pubmed/23629758 http://dx.doi.org/10.3390/molecules18055051 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Xiong, Liang
Zhou, Qin-Mei
Peng, Cheng
Xie, Xiao-Fang
Guo, Li
Li, Xiao-Hong
Liu, Juan
Liu, Zhao-Hua
Dai, Ou
Sesquiterpenoids from the Herb of Leonurus japonicus
title Sesquiterpenoids from the Herb of Leonurus japonicus
title_full Sesquiterpenoids from the Herb of Leonurus japonicus
title_fullStr Sesquiterpenoids from the Herb of Leonurus japonicus
title_full_unstemmed Sesquiterpenoids from the Herb of Leonurus japonicus
title_short Sesquiterpenoids from the Herb of Leonurus japonicus
title_sort sesquiterpenoids from the herb of leonurus japonicus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269672/
https://www.ncbi.nlm.nih.gov/pubmed/23629758
http://dx.doi.org/10.3390/molecules18055051
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