Design, Synthesis and Evaluation of Dual-Modality Glyco-Nanoparticles for Tumor Imaging

d-Glucosamine (DG) was conjugated to a core-cross linked polymeric micelle (CCPM) system equipped with both a near-infrared fluorophore (NIRF) and a gamma emitter ((111)In). The resultant nano-scale tumor-targeting imaging tracer, (111)In-DG-NIRF-CCPM, selectively accumulated in a human epithelial c...

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Detalles Bibliográficos
Autores principales: Zhu, Hua, Zhao, Jun, Lin, Xinfeng, Hong, Ye, Li, Chun, Yang, Zhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269689/
https://www.ncbi.nlm.nih.gov/pubmed/23722731
http://dx.doi.org/10.3390/molecules18066425
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author Zhu, Hua
Zhao, Jun
Lin, Xinfeng
Hong, Ye
Li, Chun
Yang, Zhi
author_facet Zhu, Hua
Zhao, Jun
Lin, Xinfeng
Hong, Ye
Li, Chun
Yang, Zhi
author_sort Zhu, Hua
collection PubMed
description d-Glucosamine (DG) was conjugated to a core-cross linked polymeric micelle (CCPM) system equipped with both a near-infrared fluorophore (NIRF) and a gamma emitter ((111)In). The resultant nano-scale tumor-targeting imaging tracer, (111)In-DG-NIRF-CCPM, selectively accumulated in a human epithelial carcinoma A-431 xenograft model in mice. At 24 hrs post injection, the tumor uptake was 2.62 ± 0.80 % of the injected dose per gram of tissue (%ID/g). Tumors were clearly delineated in both single-photon emission computed tomography (SPECT) and optical imaging. The results suggest that the prepared imaging tracer is a promising agent for tumor diagnosis.
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spelling pubmed-62696892018-12-17 Design, Synthesis and Evaluation of Dual-Modality Glyco-Nanoparticles for Tumor Imaging Zhu, Hua Zhao, Jun Lin, Xinfeng Hong, Ye Li, Chun Yang, Zhi Molecules Article d-Glucosamine (DG) was conjugated to a core-cross linked polymeric micelle (CCPM) system equipped with both a near-infrared fluorophore (NIRF) and a gamma emitter ((111)In). The resultant nano-scale tumor-targeting imaging tracer, (111)In-DG-NIRF-CCPM, selectively accumulated in a human epithelial carcinoma A-431 xenograft model in mice. At 24 hrs post injection, the tumor uptake was 2.62 ± 0.80 % of the injected dose per gram of tissue (%ID/g). Tumors were clearly delineated in both single-photon emission computed tomography (SPECT) and optical imaging. The results suggest that the prepared imaging tracer is a promising agent for tumor diagnosis. MDPI 2013-05-30 /pmc/articles/PMC6269689/ /pubmed/23722731 http://dx.doi.org/10.3390/molecules18066425 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Zhu, Hua
Zhao, Jun
Lin, Xinfeng
Hong, Ye
Li, Chun
Yang, Zhi
Design, Synthesis and Evaluation of Dual-Modality Glyco-Nanoparticles for Tumor Imaging
title Design, Synthesis and Evaluation of Dual-Modality Glyco-Nanoparticles for Tumor Imaging
title_full Design, Synthesis and Evaluation of Dual-Modality Glyco-Nanoparticles for Tumor Imaging
title_fullStr Design, Synthesis and Evaluation of Dual-Modality Glyco-Nanoparticles for Tumor Imaging
title_full_unstemmed Design, Synthesis and Evaluation of Dual-Modality Glyco-Nanoparticles for Tumor Imaging
title_short Design, Synthesis and Evaluation of Dual-Modality Glyco-Nanoparticles for Tumor Imaging
title_sort design, synthesis and evaluation of dual-modality glyco-nanoparticles for tumor imaging
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269689/
https://www.ncbi.nlm.nih.gov/pubmed/23722731
http://dx.doi.org/10.3390/molecules18066425
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