Synthesis and SAR Studies of Praziquantel Derivatives with Activity against Schistosoma japonicum

The synthesis and structure-activity relationship (SAR) studies of praziquantel derivatives with activity against adult Schistosoma japonicum are described. Several of them showed better worm killing activity than praziquantel and could serve as leads for further optimization.

Detalles Bibliográficos
Autores principales: Wang, Wen-Long, Song, Li-Jun, Chen, Xia, Yin, Xu-Ren, Fan, Wen-Hua, Wang, Gu-Ping, Yu, Chuan-Xin, Feng, Bainian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269691/
https://www.ncbi.nlm.nih.gov/pubmed/23912271
http://dx.doi.org/10.3390/molecules18089163
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author Wang, Wen-Long
Song, Li-Jun
Chen, Xia
Yin, Xu-Ren
Fan, Wen-Hua
Wang, Gu-Ping
Yu, Chuan-Xin
Feng, Bainian
author_facet Wang, Wen-Long
Song, Li-Jun
Chen, Xia
Yin, Xu-Ren
Fan, Wen-Hua
Wang, Gu-Ping
Yu, Chuan-Xin
Feng, Bainian
author_sort Wang, Wen-Long
collection PubMed
description The synthesis and structure-activity relationship (SAR) studies of praziquantel derivatives with activity against adult Schistosoma japonicum are described. Several of them showed better worm killing activity than praziquantel and could serve as leads for further optimization.
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spelling pubmed-62696912018-12-18 Synthesis and SAR Studies of Praziquantel Derivatives with Activity against Schistosoma japonicum Wang, Wen-Long Song, Li-Jun Chen, Xia Yin, Xu-Ren Fan, Wen-Hua Wang, Gu-Ping Yu, Chuan-Xin Feng, Bainian Molecules Article The synthesis and structure-activity relationship (SAR) studies of praziquantel derivatives with activity against adult Schistosoma japonicum are described. Several of them showed better worm killing activity than praziquantel and could serve as leads for further optimization. MDPI 2013-07-31 /pmc/articles/PMC6269691/ /pubmed/23912271 http://dx.doi.org/10.3390/molecules18089163 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Wang, Wen-Long
Song, Li-Jun
Chen, Xia
Yin, Xu-Ren
Fan, Wen-Hua
Wang, Gu-Ping
Yu, Chuan-Xin
Feng, Bainian
Synthesis and SAR Studies of Praziquantel Derivatives with Activity against Schistosoma japonicum
title Synthesis and SAR Studies of Praziquantel Derivatives with Activity against Schistosoma japonicum
title_full Synthesis and SAR Studies of Praziquantel Derivatives with Activity against Schistosoma japonicum
title_fullStr Synthesis and SAR Studies of Praziquantel Derivatives with Activity against Schistosoma japonicum
title_full_unstemmed Synthesis and SAR Studies of Praziquantel Derivatives with Activity against Schistosoma japonicum
title_short Synthesis and SAR Studies of Praziquantel Derivatives with Activity against Schistosoma japonicum
title_sort synthesis and sar studies of praziquantel derivatives with activity against schistosoma japonicum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269691/
https://www.ncbi.nlm.nih.gov/pubmed/23912271
http://dx.doi.org/10.3390/molecules18089163
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