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Synthesis and Biological Evaluation of RGD-Conjugated MEK1/2 Kinase Inhibitors for Integrin-Targeted Cancer Therapy
Two novel series of RGD-MEKI conjugates derived from a MEK1/2 kinase inhibitor—PD0325901—have been developed for integrin receptor mediated anticancer therapy. The first series, alkoxylamine analog RGD-MEKI conjugates 9a–g showed anti-proliferation activity in melanoma A375 cells by the same mechani...
Autores principales: | Li, Xiaoxiao, Hou, Jianjun, Wang, Chao, Liu, Xinjie, He, Hongyan, Xu, Ping, Yang, Zhenjun, Chen, Zili, Wu, Yun, Zhang, Lihe |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269693/ https://www.ncbi.nlm.nih.gov/pubmed/24225774 http://dx.doi.org/10.3390/molecules181113957 |
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