An Efficient and Facile Methodology for Bromination of Pyrimidine and Purine Nucleosides with Sodium Monobromoisocyanurate (SMBI)

An efficient and facile strategy has been developed for bromination of nucleosides using sodium monobromoisocyanurate (SMBI). Our methodology demonstrates bromination at the C-5 position of pyrimidine nucleosides and the C-8 position of purine nucleosides. Unprotected and also several protected nucl...

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Autores principales: Maity, Jyotirmoy, Stromberg, Roger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269699/
https://www.ncbi.nlm.nih.gov/pubmed/24132197
http://dx.doi.org/10.3390/molecules181012740
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author Maity, Jyotirmoy
Stromberg, Roger
author_facet Maity, Jyotirmoy
Stromberg, Roger
author_sort Maity, Jyotirmoy
collection PubMed
description An efficient and facile strategy has been developed for bromination of nucleosides using sodium monobromoisocyanurate (SMBI). Our methodology demonstrates bromination at the C-5 position of pyrimidine nucleosides and the C-8 position of purine nucleosides. Unprotected and also several protected nucleosides were brominated in moderate to high yields following this procedure.
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spelling pubmed-62696992018-12-18 An Efficient and Facile Methodology for Bromination of Pyrimidine and Purine Nucleosides with Sodium Monobromoisocyanurate (SMBI) Maity, Jyotirmoy Stromberg, Roger Molecules Article An efficient and facile strategy has been developed for bromination of nucleosides using sodium monobromoisocyanurate (SMBI). Our methodology demonstrates bromination at the C-5 position of pyrimidine nucleosides and the C-8 position of purine nucleosides. Unprotected and also several protected nucleosides were brominated in moderate to high yields following this procedure. MDPI 2013-10-15 /pmc/articles/PMC6269699/ /pubmed/24132197 http://dx.doi.org/10.3390/molecules181012740 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Maity, Jyotirmoy
Stromberg, Roger
An Efficient and Facile Methodology for Bromination of Pyrimidine and Purine Nucleosides with Sodium Monobromoisocyanurate (SMBI)
title An Efficient and Facile Methodology for Bromination of Pyrimidine and Purine Nucleosides with Sodium Monobromoisocyanurate (SMBI)
title_full An Efficient and Facile Methodology for Bromination of Pyrimidine and Purine Nucleosides with Sodium Monobromoisocyanurate (SMBI)
title_fullStr An Efficient and Facile Methodology for Bromination of Pyrimidine and Purine Nucleosides with Sodium Monobromoisocyanurate (SMBI)
title_full_unstemmed An Efficient and Facile Methodology for Bromination of Pyrimidine and Purine Nucleosides with Sodium Monobromoisocyanurate (SMBI)
title_short An Efficient and Facile Methodology for Bromination of Pyrimidine and Purine Nucleosides with Sodium Monobromoisocyanurate (SMBI)
title_sort efficient and facile methodology for bromination of pyrimidine and purine nucleosides with sodium monobromoisocyanurate (smbi)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269699/
https://www.ncbi.nlm.nih.gov/pubmed/24132197
http://dx.doi.org/10.3390/molecules181012740
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