Antitumor, Antioxidant and Antimicrobial Studies of Substituted Pyridylguanidines

A series of N-pivaloyl-N′-(alkyl/aryl)-N″-pyridylguanidine of general formula C(4)H(9)CONHC(NR(1)R(2))NPy have been synthesized and characterized using elemental analysis, FT-IR, multinuclear NMR spectroscopy, and in the case of compounds 7 and 11, by single crystal X-ray diffraction (XRD). The synt...

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Detalles Bibliográficos
Autores principales: Said, Muhammad, Badshah, Amin, Shah, Naseer Ali, Khan, Hizbullah, Murtaza, Ghulam, Vabre, Boris, Zargarian, Davit, Khan, Muhammad Rashid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269704/
https://www.ncbi.nlm.nih.gov/pubmed/23985956
http://dx.doi.org/10.3390/molecules180910378
Descripción
Sumario:A series of N-pivaloyl-N′-(alkyl/aryl)-N″-pyridylguanidine of general formula C(4)H(9)CONHC(NR(1)R(2))NPy have been synthesized and characterized using elemental analysis, FT-IR, multinuclear NMR spectroscopy, and in the case of compounds 7 and 11, by single crystal X-ray diffraction (XRD). The synthesized guanidines were tested for antitumor activities against potato tumor, and showed excellent inhibition against Agrobacterium tumefaciens (AT10)-induced tumor. The antioxidant and antimicrobial activities of these new compounds against various bacterial and fungal strains were also investigated.

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