Antitumor, Antioxidant and Antimicrobial Studies of Substituted Pyridylguanidines

A series of N-pivaloyl-N′-(alkyl/aryl)-N″-pyridylguanidine of general formula C(4)H(9)CONHC(NR(1)R(2))NPy have been synthesized and characterized using elemental analysis, FT-IR, multinuclear NMR spectroscopy, and in the case of compounds 7 and 11, by single crystal X-ray diffraction (XRD). The synt...

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Autores principales: Said, Muhammad, Badshah, Amin, Shah, Naseer Ali, Khan, Hizbullah, Murtaza, Ghulam, Vabre, Boris, Zargarian, Davit, Khan, Muhammad Rashid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269704/
https://www.ncbi.nlm.nih.gov/pubmed/23985956
http://dx.doi.org/10.3390/molecules180910378
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author Said, Muhammad
Badshah, Amin
Shah, Naseer Ali
Khan, Hizbullah
Murtaza, Ghulam
Vabre, Boris
Zargarian, Davit
Khan, Muhammad Rashid
author_facet Said, Muhammad
Badshah, Amin
Shah, Naseer Ali
Khan, Hizbullah
Murtaza, Ghulam
Vabre, Boris
Zargarian, Davit
Khan, Muhammad Rashid
author_sort Said, Muhammad
collection PubMed
description A series of N-pivaloyl-N′-(alkyl/aryl)-N″-pyridylguanidine of general formula C(4)H(9)CONHC(NR(1)R(2))NPy have been synthesized and characterized using elemental analysis, FT-IR, multinuclear NMR spectroscopy, and in the case of compounds 7 and 11, by single crystal X-ray diffraction (XRD). The synthesized guanidines were tested for antitumor activities against potato tumor, and showed excellent inhibition against Agrobacterium tumefaciens (AT10)-induced tumor. The antioxidant and antimicrobial activities of these new compounds against various bacterial and fungal strains were also investigated.
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spelling pubmed-62697042018-12-18 Antitumor, Antioxidant and Antimicrobial Studies of Substituted Pyridylguanidines Said, Muhammad Badshah, Amin Shah, Naseer Ali Khan, Hizbullah Murtaza, Ghulam Vabre, Boris Zargarian, Davit Khan, Muhammad Rashid Molecules Article A series of N-pivaloyl-N′-(alkyl/aryl)-N″-pyridylguanidine of general formula C(4)H(9)CONHC(NR(1)R(2))NPy have been synthesized and characterized using elemental analysis, FT-IR, multinuclear NMR spectroscopy, and in the case of compounds 7 and 11, by single crystal X-ray diffraction (XRD). The synthesized guanidines were tested for antitumor activities against potato tumor, and showed excellent inhibition against Agrobacterium tumefaciens (AT10)-induced tumor. The antioxidant and antimicrobial activities of these new compounds against various bacterial and fungal strains were also investigated. MDPI 2013-08-27 /pmc/articles/PMC6269704/ /pubmed/23985956 http://dx.doi.org/10.3390/molecules180910378 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Said, Muhammad
Badshah, Amin
Shah, Naseer Ali
Khan, Hizbullah
Murtaza, Ghulam
Vabre, Boris
Zargarian, Davit
Khan, Muhammad Rashid
Antitumor, Antioxidant and Antimicrobial Studies of Substituted Pyridylguanidines
title Antitumor, Antioxidant and Antimicrobial Studies of Substituted Pyridylguanidines
title_full Antitumor, Antioxidant and Antimicrobial Studies of Substituted Pyridylguanidines
title_fullStr Antitumor, Antioxidant and Antimicrobial Studies of Substituted Pyridylguanidines
title_full_unstemmed Antitumor, Antioxidant and Antimicrobial Studies of Substituted Pyridylguanidines
title_short Antitumor, Antioxidant and Antimicrobial Studies of Substituted Pyridylguanidines
title_sort antitumor, antioxidant and antimicrobial studies of substituted pyridylguanidines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269704/
https://www.ncbi.nlm.nih.gov/pubmed/23985956
http://dx.doi.org/10.3390/molecules180910378
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