In Vitro Antiprotozoal Activity of Triterpenoid Constituents of Kleinia odora Growing in Saudi Arabia

Two lupane and four ursane triterpenes, namely epilupeol (1), lupeol acetate (2), ursolic acid (3), brein (4), 3β 11α-dihydroxy urs-12-ene (5) and ursolic acid lactone (6) were isolated from aerial parts of Kleinia odora and identified. Compounds 1 and 3–6 were isolated for the first time from K. od...

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Autores principales: Al Musayeib, Nawal M., Mothana, Ramzi A., El Gamal, Ali A., Al-Massarani, Shaza M., Maes, Louis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269755/
https://www.ncbi.nlm.nih.gov/pubmed/23912274
http://dx.doi.org/10.3390/molecules18089207
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author Al Musayeib, Nawal M.
Mothana, Ramzi A.
El Gamal, Ali A.
Al-Massarani, Shaza M.
Maes, Louis
author_facet Al Musayeib, Nawal M.
Mothana, Ramzi A.
El Gamal, Ali A.
Al-Massarani, Shaza M.
Maes, Louis
author_sort Al Musayeib, Nawal M.
collection PubMed
description Two lupane and four ursane triterpenes, namely epilupeol (1), lupeol acetate (2), ursolic acid (3), brein (4), 3β 11α-dihydroxy urs-12-ene (5) and ursolic acid lactone (6) were isolated from aerial parts of Kleinia odora and identified. Compounds 1 and 3–6 were isolated for the first time from K. odora. The triterpene constituents were investigated for antiprotozoal potential against erythrocytic schizonts of Plasmodium falciparum, intracellular amastigotes of Leishmania infantum and Trypanosoma cruzi and free trypomastigotes of T. brucei. Cytotoxicity was determined against MRC-5 fibroblasts to assess selectivity. The ursane triterpenes were found to be active against more than one type of the tested parasites, with the exception of compound 6. This is also the first report on the occurrence of ursane type triterpenes in the genus Kleinia and their antiprotozoal potential against P. falciparum, L. infantum, T. cruzi, and T. brucei.
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spelling pubmed-62697552018-12-18 In Vitro Antiprotozoal Activity of Triterpenoid Constituents of Kleinia odora Growing in Saudi Arabia Al Musayeib, Nawal M. Mothana, Ramzi A. El Gamal, Ali A. Al-Massarani, Shaza M. Maes, Louis Molecules Article Two lupane and four ursane triterpenes, namely epilupeol (1), lupeol acetate (2), ursolic acid (3), brein (4), 3β 11α-dihydroxy urs-12-ene (5) and ursolic acid lactone (6) were isolated from aerial parts of Kleinia odora and identified. Compounds 1 and 3–6 were isolated for the first time from K. odora. The triterpene constituents were investigated for antiprotozoal potential against erythrocytic schizonts of Plasmodium falciparum, intracellular amastigotes of Leishmania infantum and Trypanosoma cruzi and free trypomastigotes of T. brucei. Cytotoxicity was determined against MRC-5 fibroblasts to assess selectivity. The ursane triterpenes were found to be active against more than one type of the tested parasites, with the exception of compound 6. This is also the first report on the occurrence of ursane type triterpenes in the genus Kleinia and their antiprotozoal potential against P. falciparum, L. infantum, T. cruzi, and T. brucei. MDPI 2013-07-31 /pmc/articles/PMC6269755/ /pubmed/23912274 http://dx.doi.org/10.3390/molecules18089207 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Al Musayeib, Nawal M.
Mothana, Ramzi A.
El Gamal, Ali A.
Al-Massarani, Shaza M.
Maes, Louis
In Vitro Antiprotozoal Activity of Triterpenoid Constituents of Kleinia odora Growing in Saudi Arabia
title In Vitro Antiprotozoal Activity of Triterpenoid Constituents of Kleinia odora Growing in Saudi Arabia
title_full In Vitro Antiprotozoal Activity of Triterpenoid Constituents of Kleinia odora Growing in Saudi Arabia
title_fullStr In Vitro Antiprotozoal Activity of Triterpenoid Constituents of Kleinia odora Growing in Saudi Arabia
title_full_unstemmed In Vitro Antiprotozoal Activity of Triterpenoid Constituents of Kleinia odora Growing in Saudi Arabia
title_short In Vitro Antiprotozoal Activity of Triterpenoid Constituents of Kleinia odora Growing in Saudi Arabia
title_sort in vitro antiprotozoal activity of triterpenoid constituents of kleinia odora growing in saudi arabia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269755/
https://www.ncbi.nlm.nih.gov/pubmed/23912274
http://dx.doi.org/10.3390/molecules18089207
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