Efficient Synthesis of 2-Amino-6-Arylbenzothiazoles via Pd(0) Suzuki Cross Coupling Reactions: Potent Urease Enzyme Inhibition and Nitric Oxide Scavenging Activities of the Products

In general, benzothiazole derivatives have attracted great interest due to their pharmaceutical and biological importance. New 2-amino-6-arylbenzothiazoles were synthesized in moderate to excellent yields via Suzuki cross coupling reactions using various aryl boronic acids and aryl boronic acid pina...

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Autores principales: Gull, Yasmeen, Rasool, Nasir, Noreen, Mnaza, Nasim, Faiz-ul-Hassan, Yaqoob, Asma, Kousar, Shazia, Rashid, Umer, Bukhari, Iftikhar Hussain, Zubair, Muhammad, Islam, Md. Saiful
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269778/
https://www.ncbi.nlm.nih.gov/pubmed/23892631
http://dx.doi.org/10.3390/molecules18088845
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author Gull, Yasmeen
Rasool, Nasir
Noreen, Mnaza
Nasim, Faiz-ul-Hassan
Yaqoob, Asma
Kousar, Shazia
Rashid, Umer
Bukhari, Iftikhar Hussain
Zubair, Muhammad
Islam, Md. Saiful
author_facet Gull, Yasmeen
Rasool, Nasir
Noreen, Mnaza
Nasim, Faiz-ul-Hassan
Yaqoob, Asma
Kousar, Shazia
Rashid, Umer
Bukhari, Iftikhar Hussain
Zubair, Muhammad
Islam, Md. Saiful
author_sort Gull, Yasmeen
collection PubMed
description In general, benzothiazole derivatives have attracted great interest due to their pharmaceutical and biological importance. New 2-amino-6-arylbenzothiazoles were synthesized in moderate to excellent yields via Suzuki cross coupling reactions using various aryl boronic acids and aryl boronic acid pinacol esters and the antiurease and nitric oxide (NO) scavenging activity of the products were also examined. The most active compound concerning urease enzyme inhibition was 6-phenylbenzo[d]thiazole-2-amine 3e, with an IC(50) value of 26.35 µg/mL. Compound 3c, 6-(4-methoxyphenyl) benzo[d]thiazole-2-amine, exhibited the highest nitric oxide percentage scavenging at 100 µg/mL.
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spelling pubmed-62697782018-12-18 Efficient Synthesis of 2-Amino-6-Arylbenzothiazoles via Pd(0) Suzuki Cross Coupling Reactions: Potent Urease Enzyme Inhibition and Nitric Oxide Scavenging Activities of the Products Gull, Yasmeen Rasool, Nasir Noreen, Mnaza Nasim, Faiz-ul-Hassan Yaqoob, Asma Kousar, Shazia Rashid, Umer Bukhari, Iftikhar Hussain Zubair, Muhammad Islam, Md. Saiful Molecules Article In general, benzothiazole derivatives have attracted great interest due to their pharmaceutical and biological importance. New 2-amino-6-arylbenzothiazoles were synthesized in moderate to excellent yields via Suzuki cross coupling reactions using various aryl boronic acids and aryl boronic acid pinacol esters and the antiurease and nitric oxide (NO) scavenging activity of the products were also examined. The most active compound concerning urease enzyme inhibition was 6-phenylbenzo[d]thiazole-2-amine 3e, with an IC(50) value of 26.35 µg/mL. Compound 3c, 6-(4-methoxyphenyl) benzo[d]thiazole-2-amine, exhibited the highest nitric oxide percentage scavenging at 100 µg/mL. MDPI 2013-07-25 /pmc/articles/PMC6269778/ /pubmed/23892631 http://dx.doi.org/10.3390/molecules18088845 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Gull, Yasmeen
Rasool, Nasir
Noreen, Mnaza
Nasim, Faiz-ul-Hassan
Yaqoob, Asma
Kousar, Shazia
Rashid, Umer
Bukhari, Iftikhar Hussain
Zubair, Muhammad
Islam, Md. Saiful
Efficient Synthesis of 2-Amino-6-Arylbenzothiazoles via Pd(0) Suzuki Cross Coupling Reactions: Potent Urease Enzyme Inhibition and Nitric Oxide Scavenging Activities of the Products
title Efficient Synthesis of 2-Amino-6-Arylbenzothiazoles via Pd(0) Suzuki Cross Coupling Reactions: Potent Urease Enzyme Inhibition and Nitric Oxide Scavenging Activities of the Products
title_full Efficient Synthesis of 2-Amino-6-Arylbenzothiazoles via Pd(0) Suzuki Cross Coupling Reactions: Potent Urease Enzyme Inhibition and Nitric Oxide Scavenging Activities of the Products
title_fullStr Efficient Synthesis of 2-Amino-6-Arylbenzothiazoles via Pd(0) Suzuki Cross Coupling Reactions: Potent Urease Enzyme Inhibition and Nitric Oxide Scavenging Activities of the Products
title_full_unstemmed Efficient Synthesis of 2-Amino-6-Arylbenzothiazoles via Pd(0) Suzuki Cross Coupling Reactions: Potent Urease Enzyme Inhibition and Nitric Oxide Scavenging Activities of the Products
title_short Efficient Synthesis of 2-Amino-6-Arylbenzothiazoles via Pd(0) Suzuki Cross Coupling Reactions: Potent Urease Enzyme Inhibition and Nitric Oxide Scavenging Activities of the Products
title_sort efficient synthesis of 2-amino-6-arylbenzothiazoles via pd(0) suzuki cross coupling reactions: potent urease enzyme inhibition and nitric oxide scavenging activities of the products
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269778/
https://www.ncbi.nlm.nih.gov/pubmed/23892631
http://dx.doi.org/10.3390/molecules18088845
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